Exploration of somatosensory P50 gating in schizophrenia spectrum patients: reduced P50 amplitude correlates to social anhedonia

TY - JOUR

T1 - Exploration of somatosensory P50 gating in schizophrenia spectrum patients

T2 - reduced P50 amplitude correlates to social anhedonia

AU - Arnfred, Sidse M

AU - Chen, Andrew C N

PY - 2004/2/15

Y1 - 2004/2/15

N2 - Originally, the hypothesis of a sensory gating defect in schizophrenia evolved from studies of somatosensory evoked potentials (SEP), although the idea has primarily been pursued in the auditory modality. Gating is the relative attenuation of amplitude following the second stimulus in a stimulus pair. Recently, SEP P50 gating was seen when recording the SEP P50 in a paradigm similar to the one used for auditory P50 gating. Hypothetically, abnormality of somatosensory information processing could be related to anhedonia, which is considered a core feature of schizophrenia. Twelve unmedicated, male, schizophrenia spectrum patients (seven schizophrenic and five schizotypal personality disorder patients) and 14 age-matched healthy men participated in recordings of pair-wise presented auditory and median nerve stimuli. The patients had smaller amplitudes of the SEP P50 at the first stimulus, but no gating defect. The reduced amplitude was particularly evident in subjects with high scores on the Revised Social Anhedonia Scale. Early somatosensory information processing seems abnormal in schizophrenia spectrum patients. This could be in agreement with the theory of loss of the benefit of regularity in schizophrenia, while the results are in-conclusive regarding sensory gating theory.

AB - Originally, the hypothesis of a sensory gating defect in schizophrenia evolved from studies of somatosensory evoked potentials (SEP), although the idea has primarily been pursued in the auditory modality. Gating is the relative attenuation of amplitude following the second stimulus in a stimulus pair. Recently, SEP P50 gating was seen when recording the SEP P50 in a paradigm similar to the one used for auditory P50 gating. Hypothetically, abnormality of somatosensory information processing could be related to anhedonia, which is considered a core feature of schizophrenia. Twelve unmedicated, male, schizophrenia spectrum patients (seven schizophrenic and five schizotypal personality disorder patients) and 14 age-matched healthy men participated in recordings of pair-wise presented auditory and median nerve stimuli. The patients had smaller amplitudes of the SEP P50 at the first stimulus, but no gating defect. The reduced amplitude was particularly evident in subjects with high scores on the Revised Social Anhedonia Scale. Early somatosensory information processing seems abnormal in schizophrenia spectrum patients. This could be in agreement with the theory of loss of the benefit of regularity in schizophrenia, while the results are in-conclusive regarding sensory gating theory.

KW - Adult

KW - Diagnostic and Statistical Manual of Mental Disorders

KW - Evoked Potentials, Auditory/physiology

KW - Evoked Potentials, Somatosensory/physiology

KW - Humans

KW - Male

KW - Parietal Lobe/physiopathology

KW - Schizophrenia/classification

KW - Smoking/epidemiology

KW - Social Behavior

U2 - 10.1016/j.psychres.2003.12.008

DO - 10.1016/j.psychres.2003.12.008

M3 - Journal article

C2 - 15006438

SN - 0165-1781

VL - 125

SP - 147

EP - 160

JO - Psychiatry Research

JF - Psychiatry Research

IS - 2

ER -