Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)

H. K. Strøm; M. Ohtani; B. Nowak; T. S. Boutrup; B. Jones; M. K. Raida; A. M. Bojesen

doi:10.1111/jfd.12754

Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)

H. K. Strøm, M. Ohtani, B. Nowak, T. S. Boutrup, B. Jones, M. K. Raida, A. M. Bojesen^*

^*Corresponding author af dette arbejde

3 Citationer (Scopus)

Abstract

Pathological manifestations in rainbow trout (Oncorhynchus mykiss) following experimental waterborne infection with Yersinia ruckeri serotype O1 biotype 2 (strain 07111224) were investigated. Rainbow trout were exposed to 8 × 10⁷ CFU/ml of Y. ruckeri by bath for 6 hr, and mortality was then monitored for 22 days post-infection (dpi). Organs were sampled at 3 dpi and also from moribund fish showing signs of severe systemic infection such as bleeding, exophthalmia or erratic swimming behaviour. Y. ruckeri was observed in the meninges and diencephalon of the brain, and lamina propria of olfactory organ at 3 dpi. At 12 dpi, Y. ruckeri had spread throughout the brain including cranial connective tissues and ventricles and the infection was associated with haemorrhages and an infiltration with leucocytes. Y. ruckeri infection and associated with leucocyte infiltration were observed at 13 dpi. In conclusion, Y. ruckeri strain 07111224 causes encephalitis in the acute phase of infection, which could explain why Y. ruckeri-affected fish show exophthalmia and erratic swimming known as signs of ERM.

Originalsprog	Engelsk
Tidsskrift	Journal of Fish Diseases
Vol/bind	41
Udgave nummer	3
Sider (fra-til)	529-537
Antal sider	9
ISSN	0140-7775
DOI	https://doi.org/10.1111/jfd.12754
Status	Udgivet - mar. 2018

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10.1111/jfd.12754

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@article{75482b7c74674737b0ac097433a63d33,

title = "Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)",

abstract = "Pathological manifestations in rainbow trout (Oncorhynchus mykiss) following experimental waterborne infection with Yersinia ruckeri serotype O1 biotype 2 (strain 07111224) were investigated. Rainbow trout were exposed to 8 × 107 CFU/ml of Y. ruckeri by bath for 6 hr, and mortality was then monitored for 22 days post-infection (dpi). Organs were sampled at 3 dpi and also from moribund fish showing signs of severe systemic infection such as bleeding, exophthalmia or erratic swimming behaviour. Y. ruckeri was observed in the meninges and diencephalon of the brain, and lamina propria of olfactory organ at 3 dpi. At 12 dpi, Y. ruckeri had spread throughout the brain including cranial connective tissues and ventricles and the infection was associated with haemorrhages and an infiltration with leucocytes. Y. ruckeri infection and associated with leucocyte infiltration were observed at 13 dpi. In conclusion, Y. ruckeri strain 07111224 causes encephalitis in the acute phase of infection, which could explain why Y. ruckeri-affected fish show exophthalmia and erratic swimming known as signs of ERM.",

keywords = "Central nervous system, Encephalitis, Olfactory organ, Ventriculitis, Yersinia ruckeri serotype O1 biotype 2",

author = "Str{\o}m, {H. K.} and M. Ohtani and B. Nowak and Boutrup, {T. S.} and B. Jones and Raida, {M. K.} and Bojesen, {A. M.}",

year = "2018",

month = mar,

doi = "10.1111/jfd.12754",

language = "English",

volume = "41",

pages = "529--537",

journal = "Journal of Fish Diseases",

issn = "0140-7775",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)

AU - Strøm, H. K.

AU - Ohtani, M.

AU - Nowak, B.

AU - Boutrup, T. S.

AU - Jones, B.

AU - Raida, M. K.

AU - Bojesen, A. M.

PY - 2018/3

Y1 - 2018/3

N2 - Pathological manifestations in rainbow trout (Oncorhynchus mykiss) following experimental waterborne infection with Yersinia ruckeri serotype O1 biotype 2 (strain 07111224) were investigated. Rainbow trout were exposed to 8 × 107 CFU/ml of Y. ruckeri by bath for 6 hr, and mortality was then monitored for 22 days post-infection (dpi). Organs were sampled at 3 dpi and also from moribund fish showing signs of severe systemic infection such as bleeding, exophthalmia or erratic swimming behaviour. Y. ruckeri was observed in the meninges and diencephalon of the brain, and lamina propria of olfactory organ at 3 dpi. At 12 dpi, Y. ruckeri had spread throughout the brain including cranial connective tissues and ventricles and the infection was associated with haemorrhages and an infiltration with leucocytes. Y. ruckeri infection and associated with leucocyte infiltration were observed at 13 dpi. In conclusion, Y. ruckeri strain 07111224 causes encephalitis in the acute phase of infection, which could explain why Y. ruckeri-affected fish show exophthalmia and erratic swimming known as signs of ERM.

AB - Pathological manifestations in rainbow trout (Oncorhynchus mykiss) following experimental waterborne infection with Yersinia ruckeri serotype O1 biotype 2 (strain 07111224) were investigated. Rainbow trout were exposed to 8 × 107 CFU/ml of Y. ruckeri by bath for 6 hr, and mortality was then monitored for 22 days post-infection (dpi). Organs were sampled at 3 dpi and also from moribund fish showing signs of severe systemic infection such as bleeding, exophthalmia or erratic swimming behaviour. Y. ruckeri was observed in the meninges and diencephalon of the brain, and lamina propria of olfactory organ at 3 dpi. At 12 dpi, Y. ruckeri had spread throughout the brain including cranial connective tissues and ventricles and the infection was associated with haemorrhages and an infiltration with leucocytes. Y. ruckeri infection and associated with leucocyte infiltration were observed at 13 dpi. In conclusion, Y. ruckeri strain 07111224 causes encephalitis in the acute phase of infection, which could explain why Y. ruckeri-affected fish show exophthalmia and erratic swimming known as signs of ERM.

KW - Central nervous system

KW - Encephalitis

KW - Olfactory organ

KW - Ventriculitis

KW - Yersinia ruckeri serotype O1 biotype 2

U2 - 10.1111/jfd.12754

DO - 10.1111/jfd.12754

M3 - Journal article

C2 - 29148587

AN - SCOPUS:85034259285

SN - 0140-7775

VL - 41

SP - 529

EP - 537

JO - Journal of Fish Diseases

JF - Journal of Fish Diseases

IS - 3

ER -

Experimental infection by Yersinia ruckeri O1 biotype 2 induces brain lesions and neurological signs in rainbow trout (Oncorhynchus mykiss)

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