Expanding the range of ZNF804A variants conferring risk of psychosis

S Steinberg; Ole Mors; Anders Børglum; O Gustafsson; T Werge; P B Mortensen; O A Andreassen; E Sigurdsson; T E Thorgeirsson; Y Böttcher; P Olason; R A Ophoff; S Cichon; I H Gudjonsdottir; O P H Pietiläinen; Mette Nyegaard; A Tuulio-Henriksson; A Ingason; Thomas Folkmann Hansen; L Athanasiu; J Suvisaari; J Lonnqvist; T Paunio; A Hartmann; G Jürgens; M Nordentoft; D Hougaard; B Norgaard-Pedersen; R Breuer; H-J Möller; I Giegling; B Glenthøj; H B Rasmussen; M Mattheisen; I Bitter; J M Réthelyi; T Sigmundsson; R Fossdal; U Thorsteinsdottir; M Ruggeri; S Tosato; E Strengman; Genetic Risk and Outcome in Psychosis; L A Kiemeney; I Melle; S Djurovic; L Abramova; V Kaleda; M Walshe; E Bramon; E Vassos

doi:10.1038/mp.2009.149

Expanding the range of ZNF804A variants conferring risk of psychosis

S Steinberg, Ole Mors, Anders Børglum, O Gustafsson, T Werge, P B Mortensen, O A Andreassen, E Sigurdsson, T E Thorgeirsson, Y Böttcher, P Olason, R A Ophoff, S Cichon, I H Gudjonsdottir, O P H Pietiläinen, Mette Nyegaard, A Tuulio-Henriksson, A Ingason, Thomas Folkmann Hansen, L AthanasiuJ Suvisaari, J Lonnqvist, T Paunio, A Hartmann, G Jürgens, M Nordentoft, D Hougaard, B Norgaard-Pedersen, R Breuer, H-J Möller, I Giegling, B Glenthøj, H B Rasmussen, M Mattheisen, I Bitter, J M Réthelyi, T Sigmundsson, R Fossdal, U Thorsteinsdottir, M Ruggeri, S Tosato, E Strengman, Genetic Risk and Outcome in Psychosis, L A Kiemeney, I Melle, S Djurovic, L Abramova, V Kaleda, M Walshe, E Bramon, E Vassos

122 Citationer (Scopus)

Abstract

A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders).

Originalsprog	Engelsk
Tidsskrift	Molecular Psychiatry
Vol/bind	16
Udgave nummer	1
Sider (fra-til)	59-66
Antal sider	8
ISSN	1359-4184
DOI	https://doi.org/10.1038/mp.2009.149 https://doi.org/10.1038/mp.2009.149
Status	Udgivet - 1 jan. 2011

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Steinberg, S., Mors, O., Børglum, A., Gustafsson, O., Werge, T., Mortensen, P. B., Andreassen, O. A., Sigurdsson, E., Thorgeirsson, T. E., Böttcher, Y., Olason, P., Ophoff, R. A., Cichon, S., Gudjonsdottir, I. H., Pietiläinen, O. P. H., Nyegaard, M., Tuulio-Henriksson, A., Ingason, A., Hansen, T. F., ... Vassos, E. (2011). Expanding the range of ZNF804A variants conferring risk of psychosis. Molecular Psychiatry, 16(1), 59-66. https://doi.org/10.1038/mp.2009.149, https://doi.org/10.1038/mp.2009.149

Steinberg, S, Mors, O, Børglum, A, Gustafsson, O, Werge, T, Mortensen, PB, Andreassen, OA, Sigurdsson, E, Thorgeirsson, TE, Böttcher, Y, Olason, P, Ophoff, RA, Cichon, S, Gudjonsdottir, IH, Pietiläinen, OPH, Nyegaard, M, Tuulio-Henriksson, A, Ingason, A , Hansen, TF, Athanasiu, L, Suvisaari, J, Lonnqvist, J, Paunio, T, Hartmann, A, Jürgens, G, Nordentoft, M, Hougaard, D, Norgaard-Pedersen, B, Breuer, R, Möller, H-J, Giegling, I, Glenthøj, B , Rasmussen, HB, Mattheisen, M, Bitter, I, Réthelyi, JM, Sigmundsson, T, Fossdal, R, Thorsteinsdottir, U, Ruggeri, M, Tosato, S, Strengman, E, Genetic Risk and Outcome in Psychosis, Kiemeney, LA, Melle, I, Djurovic, S, Abramova, L, Kaleda, V, Walshe, M, Bramon, E & Vassos, E 2011, 'Expanding the range of ZNF804A variants conferring risk of psychosis', Molecular Psychiatry, bind 16, nr. 1, s. 59-66. https://doi.org/10.1038/mp.2009.149, https://doi.org/10.1038/mp.2009.149

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title = "Expanding the range of ZNF804A variants conferring risk of psychosis",

abstract = "A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders).",

author = "S Steinberg and Ole Mors and Anders B{\o}rglum and O Gustafsson and T Werge and Mortensen, {P B} and Andreassen, {O A} and E Sigurdsson and Thorgeirsson, {T E} and Y B{\"o}ttcher and P Olason and Ophoff, {R A} and S Cichon and Gudjonsdottir, {I H} and Pietil{\"a}inen, {O P H} and Mette Nyegaard and A Tuulio-Henriksson and A Ingason and Hansen, {Thomas Folkmann} and L Athanasiu and J Suvisaari and J Lonnqvist and T Paunio and A Hartmann and G J{\"u}rgens and M Nordentoft and D Hougaard and B Norgaard-Pedersen and R Breuer and H-J M{\"o}ller and I Giegling and B Glenth{\o}j and Rasmussen, {H B} and M Mattheisen and I Bitter and R{\'e}thelyi, {J M} and T Sigmundsson and R Fossdal and U Thorsteinsdottir and M Ruggeri and S Tosato and E Strengman and Thomas Werge and Kiemeney, {L A} and I Melle and S Djurovic and L Abramova and V Kaleda and M Walshe and E Bramon and E Vassos",

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T1 - Expanding the range of ZNF804A variants conferring risk of psychosis

AU - Steinberg, S

AU - Mors, Ole

AU - Børglum, Anders

AU - Gustafsson, O

AU - Werge, T

AU - Mortensen, P B

AU - Andreassen, O A

AU - Sigurdsson, E

AU - Thorgeirsson, T E

AU - Böttcher, Y

AU - Olason, P

AU - Ophoff, R A

AU - Cichon, S

AU - Gudjonsdottir, I H

AU - Pietiläinen, O P H

AU - Nyegaard, Mette

AU - Tuulio-Henriksson, A

AU - Ingason, A

AU - Hansen, Thomas Folkmann

AU - Athanasiu, L

AU - Suvisaari, J

AU - Lonnqvist, J

AU - Paunio, T

AU - Hartmann, A

AU - Jürgens, G

AU - Nordentoft, M

AU - Hougaard, D

AU - Norgaard-Pedersen, B

AU - Breuer, R

AU - Möller, H-J

AU - Giegling, I

AU - Glenthøj, B

AU - Rasmussen, H B

AU - Mattheisen, M

AU - Bitter, I

AU - Réthelyi, J M

AU - Sigmundsson, T

AU - Fossdal, R

AU - Thorsteinsdottir, U

AU - Ruggeri, M

AU - Tosato, S

AU - Strengman, E

AU - Genetic Risk and Outcome in Psychosis

AU - Kiemeney, L A

AU - Melle, I

AU - Djurovic, S

AU - Abramova, L

AU - Kaleda, V

AU - Walshe, M

AU - Bramon, E

AU - Vassos, E

PY - 2011/1/1

Y1 - 2011/1/1

N2 - A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders).

AB - A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P5 × 10 8) associated with schizophrenia earlier. However, one variant, rs1344706T, had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10 7, and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10 8. In this study, using 5164 schizophrenia cases and 20 709 controls, we replicated the association with schizophrenia (odds ratio OR1.08, P0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N609, OR1.09, P0.00065). Furthermore, as it has been proposed that variants such as rs1344706Tcommon and with low relative riskmay also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39 481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P0.0016 for association with the larger set of psychiatric disorders).

U2 - 10.1038/mp.2009.149

DO - 10.1038/mp.2009.149

M3 - Journal article

C2 - 20048749

SN - 1359-4184

VL - 16

SP - 59

EP - 66

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 1

ER -

Expanding the range of ZNF804A variants conferring risk of psychosis

Abstract

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