Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

Helle Friis Proschowsky; Merete Fredholm

doi:10.1111/j.1365-2052.2007.01570.x

Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

Helle Friis Proschowsky, Merete Fredholm

7 Citationer (Scopus)

Abstract

Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.

Originalsprog	Engelsk
Tidsskrift	Animal Genetics
Vol/bind	38
Udgave nummer	2
Sider (fra-til)	171-173
Antal sider	3
ISSN	0268-9146
DOI	https://doi.org/10.1111/j.1365-2052.2007.01570.x
Status	Udgivet - 2007

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title = "Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes",

abstract = "Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.",

keywords = "Former LIFE faculty, canine, cholecystokinin, Eurasian dog, exocrine pancreaTIC insufficiency, inheritance, segregation",

author = "Proschowsky, {Helle Friis} and Merete Fredholm",

year = "2007",

doi = "10.1111/j.1365-2052.2007.01570.x",

language = "English",

volume = "38",

pages = "171--173",

journal = "Animal Genetics",

issn = "0268-9146",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

AU - Proschowsky, Helle Friis

AU - Fredholm, Merete

PY - 2007

Y1 - 2007

N2 - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.

AB - Exocrine pancreatic insufficiency is considered an inherited disease in several dog breeds. Affected dogs show polyphagia, weight loss and voluminous faeces of light colour due to the lack of pancreatic enzymes. In the study described herein, we performed a segregation analysis using the SINGLES method for three families of the Eurasian dog breed. Our data were consistent with an autosomal recessive mode of inheritance. In addition, we performed a linkage analysis in these families using four microsatellite markers on CFA3 and two microsatellites on CFA23. Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.

KW - Former LIFE faculty

KW - canine

KW - cholecystokinin

KW - Eurasian dog

KW - exocrine pancreaTIC insufficiency

KW - inheritance

KW - segregation

U2 - 10.1111/j.1365-2052.2007.01570.x

DO - 10.1111/j.1365-2052.2007.01570.x

M3 - Journal article

C2 - 17302791

SN - 0268-9146

VL - 38

SP - 171

EP - 173

JO - Animal Genetics

JF - Animal Genetics

IS - 2

ER -

Exocrine pancreatic insufficiency in the Eurasian dog breed - inheritance and exclusion of two candidate genes

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