Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging

Michala Holm Reichkendler; Pernille Landrock Auerbach; Mads Rosenkilde Larsen; Anders N. Christensen; Søren Holm; Martin Bæk Petersen; Anders Lagerberg; Henrik B W Larsson; Egill Rostrup; Thomas Hammershaimb Mosbech; Anders Mikael Sjödin; Andreas Kjaer; Thorkil Ploug; Liselotte Hoejgaard; Bente Merete Stallknecht

doi:10.1152/ajpendo.00128.2013

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging

Michala Holm Reichkendler, Pernille Landrock Auerbach, Mads Rosenkilde Larsen, Anders N. Christensen, Søren Holm, Martin Bæk Petersen, Anders Lagerberg, Henrik B W Larsson, Egill Rostrup, Thomas Hammershaimb Mosbech, Anders Mikael Sjödin, Andreas Kjaer, Thorkil Ploug, Liselotte Hoejgaard, Bente Merete Stallknecht

42 Citationer (Scopus)

Abstract

Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions, using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-[¹⁸F]fluoro-D-glucose (FDG) PET/CT methodology during steady-state insulin infusion (40 mU·m^-2·min^-1). Body composition was measured by dual X-ray absorptiometry and MRI. Sixty-one healthy, sedentary [VO_2max 36(5) ml·kg^-1·min^-1; mean(SD)], moderately overweight [BMI 28.1(1.8) kg/m²], young [age: 30(6) yr] men were randomized to sedentary living (CON; n = 17 completers) or moderate (MOD; 300 kcal/day, n = 18) or high (HIGH; 600 kcal/day, n = 18) dose physical exercise for 11 wk. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior + posterior) subcutaneous adipose tissue (SAT), and femoral SAT (P < 0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD 24[9, 39] μmol·kg^-1·min^-1, P = 0.004; HIGH 22[9, 35] μmol·kg^-1·min^-1, P = 0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized uptake value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT compared with CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups, and the decrease was distributed equally among subcutaneous and intra-abdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology: Endocrinology and Metabolism
Vol/bind	305
Udgave nummer	4
Sider (fra-til)	E496-506
Antal sider	11
ISSN	0193-1849
DOI	https://doi.org/10.1152/ajpendo.00128.2013
Status	Udgivet - 8 maj 2013

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10.1152/ajpendo.00128.2013

Citationsformater

Reichkendler, M. H., Auerbach, P. L., Larsen, M. R., Christensen, A. N., Holm, S., Petersen, M. B., Lagerberg, A., Larsson, H. B. W., Rostrup, E., Mosbech, T. H., Sjödin, A. M., Kjaer, A., Ploug, T., Hoejgaard, L., & Stallknecht, B. M. (2013). Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging. American Journal of Physiology: Endocrinology and Metabolism, 305(4), E496-506. https://doi.org/10.1152/ajpendo.00128.2013

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging. / Reichkendler, Michala Holm; Auerbach, Pernille Landrock; Larsen, Mads Rosenkilde et al.
I: American Journal of Physiology: Endocrinology and Metabolism, Bind 305, Nr. 4, 08.05.2013, s. E496-506.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Reichkendler, MH, Auerbach, PL, Larsen, MR, Christensen, AN, Holm, S, Petersen, MB, Lagerberg, A, Larsson, HBW, Rostrup, E, Mosbech, TH, Sjödin, AM , Kjaer, A , Ploug, T , Hoejgaard, L & Stallknecht, BM 2013, 'Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging', American Journal of Physiology: Endocrinology and Metabolism, bind 305, nr. 4, s. E496-506. https://doi.org/10.1152/ajpendo.00128.2013

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title = "Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging",

abstract = "Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions, using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT methodology during steady-state insulin infusion (40 mU·m-2·min-1). Body composition was measured by dual X-ray absorptiometry and MRI. Sixty-one healthy, sedentary [VO2max 36(5) ml·kg-1·min-1; mean(SD)], moderately overweight [BMI 28.1(1.8) kg/m2], young [age: 30(6) yr] men were randomized to sedentary living (CON; n = 17 completers) or moderate (MOD; 300 kcal/day, n = 18) or high (HIGH; 600 kcal/day, n = 18) dose physical exercise for 11 wk. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior + posterior) subcutaneous adipose tissue (SAT), and femoral SAT (P < 0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD 24[9, 39] μmol·kg-1·min-1, P = 0.004; HIGH 22[9, 35] μmol·kg-1·min-1, P = 0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized uptake value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT compared with CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups, and the decrease was distributed equally among subcutaneous and intra-abdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.",

author = "Reichkendler, {Michala Holm} and Auerbach, {Pernille Landrock} and Larsen, {Mads Rosenkilde} and Christensen, {Anders N.} and S{\o}ren Holm and Petersen, {Martin B{\ae}k} and Anders Lagerberg and Larsson, {Henrik B W} and Egill Rostrup and Mosbech, {Thomas Hammershaimb} and Sj{\"o}din, {Anders Mikael} and Andreas Kjaer and Thorkil Ploug and Liselotte Hoejgaard and Stallknecht, {Bente Merete}",

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TY - JOUR

T1 - Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue

T2 - A randomized study using FDG PET imaging

AU - Reichkendler, Michala Holm

AU - Auerbach, Pernille Landrock

AU - Larsen, Mads Rosenkilde

AU - Christensen, Anders N.

AU - Holm, Søren

AU - Petersen, Martin Bæk

AU - Lagerberg, Anders

AU - Larsson, Henrik B W

AU - Rostrup, Egill

AU - Mosbech, Thomas Hammershaimb

AU - Sjödin, Anders Mikael

AU - Kjaer, Andreas

AU - Ploug, Thorkil

AU - Hoejgaard, Liselotte

AU - Stallknecht, Bente Merete

N1 - CURIS 2013 NEXS 172

PY - 2013/5/8

Y1 - 2013/5/8

N2 - Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions, using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT methodology during steady-state insulin infusion (40 mU·m-2·min-1). Body composition was measured by dual X-ray absorptiometry and MRI. Sixty-one healthy, sedentary [VO2max 36(5) ml·kg-1·min-1; mean(SD)], moderately overweight [BMI 28.1(1.8) kg/m2], young [age: 30(6) yr] men were randomized to sedentary living (CON; n = 17 completers) or moderate (MOD; 300 kcal/day, n = 18) or high (HIGH; 600 kcal/day, n = 18) dose physical exercise for 11 wk. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior + posterior) subcutaneous adipose tissue (SAT), and femoral SAT (P < 0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD 24[9, 39] μmol·kg-1·min-1, P = 0.004; HIGH 22[9, 35] μmol·kg-1·min-1, P = 0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized uptake value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT compared with CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups, and the decrease was distributed equally among subcutaneous and intra-abdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.

AB - Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions, using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT methodology during steady-state insulin infusion (40 mU·m-2·min-1). Body composition was measured by dual X-ray absorptiometry and MRI. Sixty-one healthy, sedentary [VO2max 36(5) ml·kg-1·min-1; mean(SD)], moderately overweight [BMI 28.1(1.8) kg/m2], young [age: 30(6) yr] men were randomized to sedentary living (CON; n = 17 completers) or moderate (MOD; 300 kcal/day, n = 18) or high (HIGH; 600 kcal/day, n = 18) dose physical exercise for 11 wk. At baseline, insulin-stimulated glucose uptake was highest in femoral skeletal muscle followed by intraperitoneal visceral adipose tissue (VAT), retroperitoneal VAT, abdominal (anterior + posterior) subcutaneous adipose tissue (SAT), and femoral SAT (P < 0.0001 between tissues). Metabolic rate of glucose increased similarly (~30%) in the two exercise groups in femoral skeletal muscle (MOD 24[9, 39] μmol·kg-1·min-1, P = 0.004; HIGH 22[9, 35] μmol·kg-1·min-1, P = 0.003) (mean[95% CI]) and in five individual femoral muscle groups but not in femoral SAT. Standardized uptake value of FDG decreased ~24% in anterior abdominal SAT and ~20% in posterior abdominal SAT compared with CON but not in either intra- or retroperitoneal VAT. Total adipose tissue mass decreased in both exercise groups, and the decrease was distributed equally among subcutaneous and intra-abdominal depots. In conclusion, aerobic exercise training increases insulin-stimulated glucose uptake in skeletal muscle but not in adipose tissue, which demonstrates some interregional differences.

U2 - 10.1152/ajpendo.00128.2013

DO - 10.1152/ajpendo.00128.2013

M3 - Journal article

C2 - 23800880

SN - 0193-1849

VL - 305

SP - E496-506

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

IS - 4

ER -

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging

Abstract

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