Exercise-induced phospho-proteins in skeletal muscle

A S Deshmukh; J A Hawley; J R Zierath

doi:10.1038/ijo.2008.118

Exercise-induced phospho-proteins in skeletal muscle

25 Citationer (Scopus)

Abstract

Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.

Originalsprog	Engelsk
Tidsskrift	International journal of obesity (2005)
Vol/bind	32 Suppl 4
Sider (fra-til)	S18-23
ISSN	0307-0565
DOI	https://doi.org/10.1038/ijo.2008.118
Status	Udgivet - sep. 2008

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10.1038/ijo.2008.118

Citationsformater

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abstract = "Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.",

keywords = "Animals, Exercise, GTPase-Activating Proteins, Glucose, Humans, Mice, Muscle Contraction, Muscle, Skeletal, Protein Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "Deshmukh, {A S} and Hawley, {J A} and Zierath, {J R}",

year = "2008",

month = sep,

doi = "10.1038/ijo.2008.118",

language = "English",

volume = "32 Suppl 4",

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T1 - Exercise-induced phospho-proteins in skeletal muscle

AU - Deshmukh, A S

AU - Hawley, J A

AU - Zierath, J R

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N2 - Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.

AB - Efforts to identify exercise-induced signaling events in skeletal muscle have been influenced by ground-breaking discoveries in the insulin action field. Initial discoveries demonstrating that exercise enhances insulin sensitivity raised the possibility that contraction directly modulates insulin receptor signaling events. Although the acute effects of exercise on glucose metabolism are clearly insulin-independent, the canonical insulin signaling cascade has been used as a framework by investigators in an attempt to resolve the mechanisms by which muscle contraction governs glucose metabolism. This review focuses on recent advances in our understanding of exercise-induced signaling pathways governing glucose metabolism in skeletal muscle. Particular emphasis will be placed on the characterization of AS160, a novel Akt substrate that plays a role in the regulation of glucose transport.

KW - Animals

KW - Exercise

KW - GTPase-Activating Proteins

KW - Glucose

KW - Humans

KW - Mice

KW - Muscle Contraction

KW - Muscle, Skeletal

KW - Protein Kinases

KW - Proto-Oncogene Proteins c-akt

KW - Signal Transduction

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1038/ijo.2008.118

DO - 10.1038/ijo.2008.118

M3 - Journal article

C2 - 18719593

SN - 0307-0565

VL - 32 Suppl 4

SP - S18-23

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

Exercise-induced phospho-proteins in skeletal muscle

Abstract

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