Exercise-induced improvement in cognitive performance after fimbria-fornix transection depends on the timing of exercise administration

TY - JOUR

T1 - Exercise-induced improvement in cognitive performance after fimbria-fornix transection depends on the timing of exercise administration

AU - Gram, Marie Gajhede

AU - Wogensen, Elise

AU - Moseholm, Kristine

AU - Mogensen, Jesper

AU - Rytter, Hana Malá

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background Exercise after brain injury holds major therapeutic potentials, but it is still uncertain whether such an intervention should take place during the critical time window of intrinsic repair mechanisms. Objective To assess the effects of acute or delayed voluntary exercise in running wheels on post-injury allocentric place learning in an 8-arm radial maze. Methods Forty-eight pre-shaped male rats underwent fimbria-fornix transection (FF) or control surgery (Sham). The animals were divided into six groups: FF group with no access to exercise (FF/NE); FF group starting exercise 1 day post-surgery (FF/E + 1); FF group starting exercise 8 days post-surgery (FF/E + 8); FF group starting exercise 21 days post-surgery (FF/E + 21); Sham group with no access to exercise (Sham/NE), and Sham group starting exercise 1 day post-surgery (Sham/E + 1). After 7 days of exercise 6 h/day, all animals underwent 28 place learning acquisition sessions. Results The FF/E + 21 group showed an enhanced acquisition of the task compared to FF/NE. The FF/E + 1 and FF/E + 8 groups also showed an enhanced task acquisition relative to FF/NE, however with a slower acquisition than the FF/E + 21 group. Conclusion The data underscores the link between exercise and functional recovery after brain injury and emphasizes the importance of optimal timing of this intervention.

AB - Background Exercise after brain injury holds major therapeutic potentials, but it is still uncertain whether such an intervention should take place during the critical time window of intrinsic repair mechanisms. Objective To assess the effects of acute or delayed voluntary exercise in running wheels on post-injury allocentric place learning in an 8-arm radial maze. Methods Forty-eight pre-shaped male rats underwent fimbria-fornix transection (FF) or control surgery (Sham). The animals were divided into six groups: FF group with no access to exercise (FF/NE); FF group starting exercise 1 day post-surgery (FF/E + 1); FF group starting exercise 8 days post-surgery (FF/E + 8); FF group starting exercise 21 days post-surgery (FF/E + 21); Sham group with no access to exercise (Sham/NE), and Sham group starting exercise 1 day post-surgery (Sham/E + 1). After 7 days of exercise 6 h/day, all animals underwent 28 place learning acquisition sessions. Results The FF/E + 21 group showed an enhanced acquisition of the task compared to FF/NE. The FF/E + 1 and FF/E + 8 groups also showed an enhanced task acquisition relative to FF/NE, however with a slower acquisition than the FF/E + 21 group. Conclusion The data underscores the link between exercise and functional recovery after brain injury and emphasizes the importance of optimal timing of this intervention.

KW - Faculty of Social Sciences

KW - Hjerne

KW - Hippocampus

KW - Fimbria-fornix

KW - Hjerneskade

KW - Rehabilitation

KW - Funktionel genopretning

KW - Motion

KW - Rotte

KW - Dyremodel

KW - Timing

KW - place learning

KW - Cognition

KW - cognitiv rehabilitation

U2 - 10.1016/j.brainresbull.2016.06.012

DO - 10.1016/j.brainresbull.2016.06.012

M3 - Journal article

C2 - 27344001

SN - 0361-9230

VL - 125

SP - 117

EP - 126

JO - Brain Research Bulletin

JF - Brain Research Bulletin

ER -