TY - JOUR
T1 - Exercise increases circulating GDF15 in humans
AU - Kleinert, Maximilian
AU - Clemmensen, Christoffer
AU - Sjøberg, Kim Anker
AU - Carl, Christian Strini
AU - Jeppesen, Jacob Fuglsbjerg
AU - Wojtaszewski, Jørgen
AU - Kiens, Bente
AU - Richter, Erik
N1 - CURIS 2018 NEXS 060
PY - 2018/3
Y1 - 2018/3
N2 - Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO 2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.
AB - Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO 2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.
KW - Skeletal muscle
KW - Growth differentiation factor 15
KW - Recovery
KW - Physical activity
U2 - 10.1016/j.molmet.2017.12.016
DO - 10.1016/j.molmet.2017.12.016
M3 - Letter
C2 - 29398617
SN - 2212-8778
VL - 9
SP - 187
EP - 191
JO - Molecular Metabolism
JF - Molecular Metabolism
ER -