Exclusion of candidate genes for coat colour phenotypes of the American mink (Neovison vison)

Razvan Marian Anistoroaei; M. N. Markakis; K. Vissenberg; Knud Arnbjerg Christensen

doi:10.1111/j.1365-2052.2012.02339.x

Exclusion of candidate genes for coat colour phenotypes of the American mink (Neovison vison)

Razvan Marian Anistoroaei, M. N. Markakis, K. Vissenberg, Knud Arnbjerg Christensen

3 Citationer (Scopus)

Abstract

In a previous project, we screened the American mink Bacterial Artificial Chromosome library, CHORI-231, for genes potentially involved in various coat colour phenotypes in the American mink. Subsequently, we 454 sequenced the inserts containing these genes and developed microsatellite markers for each of these genes. Here, we describe a lack of association between three different ‘roan-type' phenotypes represented by Cross, Stardust and Cinnamon in American mink and six different genes that we considered to be potentially linked to these phenotypes. Thus, c-KIT (HUGO-approved symbol KIT), ATOH-1 (HUGO-approved symbol ATOH1) and POMC were excluded as potential candidates for these three phenotypes. In addition, MITF and SLC24A5 were excluded for Cross and Cinnamon, and KITL (HUGO-approved symbol KITLG) for Cross and Stardust. Although most of these genes have been implicated as the cause of similar phenotypes in other mammals, including horses, pigs, cows, dogs, cats, mice and humans, they do not appear to be responsible for comparable phenotypes found in American mink.

Originalsprog	Engelsk
Tidsskrift	Animal Genetics
Vol/bind	43
Udgave nummer	6
Sider (fra-til)	813-816
Antal sider	4
ISSN	0268-9146
DOI	https://doi.org/10.1111/j.1365-2052.2012.02339.x
Status	Udgivet - dec. 2012

Emneord

Det tidligere LIFE
American mink
Cinnamon
Cross
gene exclusion
Stardust

Adgang til dokumentet

10.1111/j.1365-2052.2012.02339.x

Citationsformater

@article{0775634ed9f34f63a6db71c9bee9b71f,

title = "Exclusion of candidate genes for coat colour phenotypes of the American mink (Neovison vison)",

abstract = "In a previous project, we screened the American mink Bacterial Artificial Chromosome library, CHORI-231, for genes potentially involved in various coat colour phenotypes in the American mink. Subsequently, we 454 sequenced the inserts containing these genes and developed microsatellite markers for each of these genes. Here, we describe a lack of association between three different {\textquoteleft}roan-type' phenotypes represented by Cross, Stardust and Cinnamon in American mink and six different genes that we considered to be potentially linked to these phenotypes. Thus, c-KIT (HUGO-approved symbol KIT), ATOH-1 (HUGO-approved symbol ATOH1) and POMC were excluded as potential candidates for these three phenotypes. In addition, MITF and SLC24A5 were excluded for Cross and Cinnamon, and KITL (HUGO-approved symbol KITLG) for Cross and Stardust. Although most of these genes have been implicated as the cause of similar phenotypes in other mammals, including horses, pigs, cows, dogs, cats, mice and humans, they do not appear to be responsible for comparable phenotypes found in American mink.",

keywords = "Former LIFE faculty, American mink, Cinnamon, Cross, gene exclusion, Stardust",

author = "Anistoroaei, {Razvan Marian} and Markakis, {M. N.} and K. Vissenberg and Christensen, {Knud Arnbjerg}",

year = "2012",

month = dec,

doi = "10.1111/j.1365-2052.2012.02339.x",

language = "English",

volume = "43",

pages = "813--816",

journal = "Animal Genetics",

issn = "0268-9146",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Exclusion of candidate genes for coat colour phenotypes of the American mink (Neovison vison)

AU - Anistoroaei, Razvan Marian

AU - Markakis, M. N.

AU - Vissenberg, K.

AU - Christensen, Knud Arnbjerg

PY - 2012/12

Y1 - 2012/12

N2 - In a previous project, we screened the American mink Bacterial Artificial Chromosome library, CHORI-231, for genes potentially involved in various coat colour phenotypes in the American mink. Subsequently, we 454 sequenced the inserts containing these genes and developed microsatellite markers for each of these genes. Here, we describe a lack of association between three different ‘roan-type' phenotypes represented by Cross, Stardust and Cinnamon in American mink and six different genes that we considered to be potentially linked to these phenotypes. Thus, c-KIT (HUGO-approved symbol KIT), ATOH-1 (HUGO-approved symbol ATOH1) and POMC were excluded as potential candidates for these three phenotypes. In addition, MITF and SLC24A5 were excluded for Cross and Cinnamon, and KITL (HUGO-approved symbol KITLG) for Cross and Stardust. Although most of these genes have been implicated as the cause of similar phenotypes in other mammals, including horses, pigs, cows, dogs, cats, mice and humans, they do not appear to be responsible for comparable phenotypes found in American mink.

AB - In a previous project, we screened the American mink Bacterial Artificial Chromosome library, CHORI-231, for genes potentially involved in various coat colour phenotypes in the American mink. Subsequently, we 454 sequenced the inserts containing these genes and developed microsatellite markers for each of these genes. Here, we describe a lack of association between three different ‘roan-type' phenotypes represented by Cross, Stardust and Cinnamon in American mink and six different genes that we considered to be potentially linked to these phenotypes. Thus, c-KIT (HUGO-approved symbol KIT), ATOH-1 (HUGO-approved symbol ATOH1) and POMC were excluded as potential candidates for these three phenotypes. In addition, MITF and SLC24A5 were excluded for Cross and Cinnamon, and KITL (HUGO-approved symbol KITLG) for Cross and Stardust. Although most of these genes have been implicated as the cause of similar phenotypes in other mammals, including horses, pigs, cows, dogs, cats, mice and humans, they do not appear to be responsible for comparable phenotypes found in American mink.

KW - Former LIFE faculty

KW - American mink

KW - Cinnamon

KW - Cross

KW - gene exclusion

KW - Stardust

U2 - 10.1111/j.1365-2052.2012.02339.x

DO - 10.1111/j.1365-2052.2012.02339.x

M3 - Journal article

C2 - 22497269

SN - 0268-9146

VL - 43

SP - 813

EP - 816

JO - Animal Genetics

JF - Animal Genetics

IS - 6

ER -