Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri

M Anctil; C J Grimmelikhuijzen

Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri

Cell- and Neurobiology

20 Citationer (Scopus)

Abstract

1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.

Originalsprog	Engelsk
Bogserie	Advances in General and Cellular Pharmacology
Vol/bind	20
Udgave nummer	3
Sider (fra-til)	381-4
Antal sider	4
ISSN	0146-3810
Status	Udgivet - 1 jan. 1989

Citationsformater

@article{8a7dcf7d250a4c28825efbe95fa6d413,

title = "Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla k{\"o}llikeri",

abstract = "1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla k{\"o}llikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.",

keywords = "Animals, Calcium, Cnidaria, Electric Stimulation, Muscle Contraction, Muscles, Neuropeptides, Pyrrolidonecarboxylic Acid",

author = "M Anctil and Grimmelikhuijzen, {C J}",

year = "1989",

month = jan,

day = "1",

language = "English",

volume = "20",

pages = "381--4",

journal = "Advances in General and Cellular Pharmacology",

issn = "0146-3810",

publisher = "Kluwer Academic / Plenum Publishers",

number = "3",

}

TY - JOUR

T1 - Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri

AU - Anctil, M

AU - Grimmelikhuijzen, C J

PY - 1989/1/1

Y1 - 1989/1/1

N2 - 1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.

AB - 1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.

KW - Animals

KW - Calcium

KW - Cnidaria

KW - Electric Stimulation

KW - Muscle Contraction

KW - Muscles

KW - Neuropeptides

KW - Pyrrolidonecarboxylic Acid

M3 - Journal article

C2 - 2568307

SN - 0146-3810

VL - 20

SP - 381

EP - 384

JO - Advances in General and Cellular Pharmacology

JF - Advances in General and Cellular Pharmacology

IS - 3

ER -

Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri

Abstract

Fingeraftryk

Citationsformater