Excessive nodular hyperplasia of brunner glands associated with gastric hypersecretion and lipomatous atrophy of the pancreas

TY - JOUR

T1 - Excessive nodular hyperplasia of brunner glands associated with gastric hypersecretion and lipomatous atrophy of the pancreas

AU - Toøttrup, A.

AU - Rokkjær, M.

AU - Kruse, A.

AU - Poulsen, S. Seier

AU - Jacobsen, N. O.

PY - 1999/7/13

Y1 - 1999/7/13

N2 - The case of a 34-year-old woman complaining of diarrhoea and abdominal pain is presented. Contrast radiography and endoscopy showed multiple polypoid tumours in the second part of the duodenum. Moreover, a severe fatty infiltration of the pancreas was shown by magnetic resonance and computed tomography scans. Due to pain, pancreatoduodenectomy (Whipple operation) was performed, and subsequent histopathologic examinations showed excessive Brunner gland hyperplasia of the duodenum and severe lipomatous atrophy of the pancreas. The occurrence of these two rare conditions in one patient has not been described previously, and it is conceivable that the lipomatous atrophy and exocrine insufficiency of the pancreas may have caused a compensatory stimulation of the submucosal structures of the duodenum.

AB - The case of a 34-year-old woman complaining of diarrhoea and abdominal pain is presented. Contrast radiography and endoscopy showed multiple polypoid tumours in the second part of the duodenum. Moreover, a severe fatty infiltration of the pancreas was shown by magnetic resonance and computed tomography scans. Due to pain, pancreatoduodenectomy (Whipple operation) was performed, and subsequent histopathologic examinations showed excessive Brunner gland hyperplasia of the duodenum and severe lipomatous atrophy of the pancreas. The occurrence of these two rare conditions in one patient has not been described previously, and it is conceivable that the lipomatous atrophy and exocrine insufficiency of the pancreas may have caused a compensatory stimulation of the submucosal structures of the duodenum.

KW - Diarrhoea

KW - Duodenal mucosa

KW - Malabsorption

KW - Pancreatic secretion

KW - Pathophysiology of the pancreas

UR - http://www.scopus.com/inward/record.url?scp=18344412743&partnerID=8YFLogxK

U2 - 10.1080/003655299750026317

DO - 10.1080/003655299750026317

M3 - Journal article

C2 - 10423074

AN - SCOPUS:18344412743

SN - 0085-5928

VL - 34

SP - 541

EP - 544

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

IS - 5

ER -