Evolution and regulation of cellular periodic processes: a role for paralogues

Kalliopi Trachana; Lars Juhl Jensen; Peer Bork

doi:10.1038/embor.2010.9

Evolution and regulation of cellular periodic processes: a role for paralogues

Kalliopi Trachana, Lars Juhl Jensen, Peer Bork

4 Citationer (Scopus)

Abstract

Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.

Originalsprog	Engelsk
Tidsskrift	E M B O Reports
Vol/bind	11
Udgave nummer	3
Sider (fra-til)	233-8
Antal sider	6
ISSN	1469-221X
DOI	https://doi.org/10.1038/embor.2010.9
Status	Udgivet - 1 mar. 2010

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10.1038/embor.2010.9

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title = "Evolution and regulation of cellular periodic processes: a role for paralogues",

abstract = "Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.",

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T1 - Evolution and regulation of cellular periodic processes: a role for paralogues

AU - Trachana, Kalliopi

AU - Jensen, Lars Juhl

AU - Bork, Peer

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.

AB - Several cyclic processes take place within a single organism. For example, the cell cycle is coordinated with the 24 h diurnal rhythm in animals and plants, and with the 40 min ultradian rhythm in budding yeast. To examine the evolution of periodic gene expression during these processes, we performed the first systematic comparison in three organisms (Homo sapiens, Arabidopsis thaliana and Saccharomyces cerevisiae) by using public microarray data. We observed that although diurnal-regulated and ultradian-regulated genes are not generally cell-cycle-regulated, they tend to have cell-cycle-regulated paralogues. Thus, diverged temporal expression of paralogues seems to facilitate cellular orchestration under different periodic stimuli. Lineage-specific functional repertoires of periodic-associated paralogues imply that this mode of regulation might have evolved independently in several organisms.

KW - Arabidopsis

KW - Cell Cycle

KW - Computational Biology

KW - Evolution, Molecular

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Fungal

KW - Gene Expression Regulation, Plant

KW - Humans

KW - Models, Biological

KW - Models, Genetic

KW - Multigene Family

KW - Oligonucleotide Array Sequence Analysis

KW - Oxidation-Reduction

KW - Saccharomyces cerevisiae

KW - Time Factors

U2 - 10.1038/embor.2010.9

DO - 10.1038/embor.2010.9

M3 - Journal article

C2 - 20168326

SN - 1469-221X

VL - 11

SP - 233

EP - 238

JO - E M B O Reports

JF - E M B O Reports

IS - 3

ER -

Evolution and regulation of cellular periodic processes: a role for paralogues

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