Evidence of no association between human papillomavirus and breast cancer

Sara Bønløkke; Jan Blaakær; Torben Steiniche; Estrid Høgdall; Steffen Grann Jensen; Anne Hammer; Eva Balslev; Mikael Lenz Strube; Helle Knakkergaard; Suzan Lenz

doi:10.3389/fonc.2018.00209

Evidence of no association between human papillomavirus and breast cancer

Sara Bønløkke^*, Jan Blaakær, Torben Steiniche, Estrid Høgdall, Steffen Grann Jensen, Anne Hammer, Eva Balslev, Mikael Lenz Strube, Helle Knakkergaard, Suzan Lenz

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

7 Citationer (Scopus)

23 Downloads (Pure)

Abstract

Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. Methods: This case-control study identified 193 Danish women diagnosed with breast cancer (1998-2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF ₁₀ PCR-DEIA-LiPA ₂₅ and an in-house semi-Q-PCR assay. Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32-4.48) and 0.52% (95% CI 0.01-2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88-0.98). Concordance between the assays was 98.60%. Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

Originalsprog	Engelsk
Artikelnummer	209
Tidsskrift	Frontiers in Oncology
Vol/bind	8
Udgave nummer	JUN
Antal sider	8
ISSN	2234-943X
DOI	https://doi.org/10.3389/fonc.2018.00209
Status	Udgivet - 2018

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title = "Evidence of no association between human papillomavirus and breast cancer",

abstract = " Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. Methods: This case-control study identified 193 Danish women diagnosed with breast cancer (1998-2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF 10 PCR-DEIA-LiPA 25 and an in-house semi-Q-PCR assay. Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32-4.48) and 0.52% (95% CI 0.01-2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88-0.98). Concordance between the assays was 98.60%. Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer. ",

keywords = "Breast cancer, Cervical cancer, Denmark, HPV, Human papillomavirus, Pathology, Polymerase chain reaction",

author = "Sara B{\o}nl{\o}kke and Jan Blaak{\ae}r and Torben Steiniche and Estrid H{\o}gdall and Jensen, {Steffen Grann} and Anne Hammer and Eva Balslev and Strube, {Mikael Lenz} and Helle Knakkergaard and Suzan Lenz",

year = "2018",

doi = "10.3389/fonc.2018.00209",

language = "English",

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journal = "Frontiers in Oncology",

issn = "2234-943X",

publisher = "Frontiers Media S.A.",

number = "JUN",

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TY - JOUR

T1 - Evidence of no association between human papillomavirus and breast cancer

AU - Bønløkke, Sara

AU - Blaakær, Jan

AU - Steiniche, Torben

AU - Høgdall, Estrid

AU - Jensen, Steffen Grann

AU - Hammer, Anne

AU - Balslev, Eva

AU - Strube, Mikael Lenz

AU - Knakkergaard, Helle

AU - Lenz, Suzan

PY - 2018

Y1 - 2018

N2 - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. Methods: This case-control study identified 193 Danish women diagnosed with breast cancer (1998-2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF 10 PCR-DEIA-LiPA 25 and an in-house semi-Q-PCR assay. Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32-4.48) and 0.52% (95% CI 0.01-2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88-0.98). Concordance between the assays was 98.60%. Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

AB - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. Methods: This case-control study identified 193 Danish women diagnosed with breast cancer (1998-2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF 10 PCR-DEIA-LiPA 25 and an in-house semi-Q-PCR assay. Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32-4.48) and 0.52% (95% CI 0.01-2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88-0.98). Concordance between the assays was 98.60%. Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

KW - Breast cancer

KW - Cervical cancer

KW - Denmark

KW - HPV

KW - Human papillomavirus

KW - Pathology

KW - Polymerase chain reaction

U2 - 10.3389/fonc.2018.00209

DO - 10.3389/fonc.2018.00209

M3 - Journal article

C2 - 29938198

AN - SCOPUS:85048598559

SN - 2234-943X

VL - 8

JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - JUN

M1 - 209

ER -

Evidence of no association between human papillomavirus and breast cancer

Abstract

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