Lagerberg, J. W., Salado-Jimena, J. A., Löf, H., Bontekoe, I. J., Nielsen, C., Verheggen, C., van Waeg, G., van der Meer, P. F., de Korte, D., Hansen, M. B., & Knutson, F. (2013). Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor. Transfusion, 53(8), 1798-1807. https://doi.org/10.1111/trf.12010
Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor. / Lagerberg, Johan W; Salado-Jimena, Jose A; Löf, Helena et al.
I:
Transfusion, Bind 53, Nr. 8, 08.2013, s. 1798-1807.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Lagerberg, JW, Salado-Jimena, JA, Löf, H, Bontekoe, IJ, Nielsen, C, Verheggen, C, van Waeg, G, van der Meer, PF, de Korte, D, Hansen, MB & Knutson, F 2013, 'Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor', Transfusion, bind 53, nr. 8, s. 1798-1807. https://doi.org/10.1111/trf.12010
Lagerberg JW, Salado-Jimena JA, Löf H, Bontekoe IJ, Nielsen C, Verheggen C et al. Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor. Transfusion. 2013 aug.;53(8):1798-1807. doi: 10.1111/trf.12010
Lagerberg, Johan W ; Salado-Jimena, Jose A ; Löf, Helena et al. / Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor. I: Transfusion. 2013 ; Bind 53, Nr. 8. s. 1798-1807.
@article{58646f5456ab4e419ebafbfc506f8b46,
title = "Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor",
abstract = "Background The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2-8 hr) or overnight-held WB. Study Design and Methods A prototype of the Reveos system was used to process WB. RBCs were resuspended in SAGM, leukoreduced, and assayed for in vitro quality variables during a 42-day storage period at 2 to 6°C. Twenty-four-hour in vivo recovery was determined on Day 42. Plasma was assayed for cellular contamination and activation variables. IPUs were pooled with SSP+ additive solution for in vitro quality assessments during a 7-day storage period at room temperature. Results Reveos-produced RBCs and plasma units met the predefined requirements. RBC recovery was superior to control units. On Day 42, hemolysis was below 0.8% and in vivo recovery was above 75% for all RBCs. Cellular contamination was lower for Reveos-produced plasma. PLT yield was higher with overnight-stored WB. PLT quality was well maintained during storage with no significant differences between the two groups. Conclusion Blood components prepared with the Reveos from fresh or overnight-held WB meet quality criteria without any relevant difference between the two groups. The Reveos system has the potential to increase efficacy and standardization of blood component preparation.",
author = "Lagerberg, {Johan W} and Salado-Jimena, {Jose A} and Helena L{\"o}f and Bontekoe, {Ido J} and Connie Nielsen and Caroline Verheggen and {van Waeg}, Geert and {van der Meer}, {Pieter F} and {de Korte}, Dirk and Hansen, {Morten B} and Folke Knutson",
year = "2013",
month = aug,
doi = "10.1111/trf.12010",
language = "English",
volume = "53",
pages = "1798--1807",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "8",
}
TY - JOUR
T1 - Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor
AU - Lagerberg, Johan W
AU - Salado-Jimena, Jose A
AU - Löf, Helena
AU - Bontekoe, Ido J
AU - Nielsen, Connie
AU - Verheggen, Caroline
AU - van Waeg, Geert
AU - van der Meer, Pieter F
AU - de Korte, Dirk
AU - Hansen, Morten B
AU - Knutson, Folke
PY - 2013/8
Y1 - 2013/8
N2 - Background The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2-8 hr) or overnight-held WB. Study Design and Methods A prototype of the Reveos system was used to process WB. RBCs were resuspended in SAGM, leukoreduced, and assayed for in vitro quality variables during a 42-day storage period at 2 to 6°C. Twenty-four-hour in vivo recovery was determined on Day 42. Plasma was assayed for cellular contamination and activation variables. IPUs were pooled with SSP+ additive solution for in vitro quality assessments during a 7-day storage period at room temperature. Results Reveos-produced RBCs and plasma units met the predefined requirements. RBC recovery was superior to control units. On Day 42, hemolysis was below 0.8% and in vivo recovery was above 75% for all RBCs. Cellular contamination was lower for Reveos-produced plasma. PLT yield was higher with overnight-stored WB. PLT quality was well maintained during storage with no significant differences between the two groups. Conclusion Blood components prepared with the Reveos from fresh or overnight-held WB meet quality criteria without any relevant difference between the two groups. The Reveos system has the potential to increase efficacy and standardization of blood component preparation.
AB - Background The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2-8 hr) or overnight-held WB. Study Design and Methods A prototype of the Reveos system was used to process WB. RBCs were resuspended in SAGM, leukoreduced, and assayed for in vitro quality variables during a 42-day storage period at 2 to 6°C. Twenty-four-hour in vivo recovery was determined on Day 42. Plasma was assayed for cellular contamination and activation variables. IPUs were pooled with SSP+ additive solution for in vitro quality assessments during a 7-day storage period at room temperature. Results Reveos-produced RBCs and plasma units met the predefined requirements. RBC recovery was superior to control units. On Day 42, hemolysis was below 0.8% and in vivo recovery was above 75% for all RBCs. Cellular contamination was lower for Reveos-produced plasma. PLT yield was higher with overnight-stored WB. PLT quality was well maintained during storage with no significant differences between the two groups. Conclusion Blood components prepared with the Reveos from fresh or overnight-held WB meet quality criteria without any relevant difference between the two groups. The Reveos system has the potential to increase efficacy and standardization of blood component preparation.
U2 - 10.1111/trf.12010
DO - 10.1111/trf.12010
M3 - Journal article
C2 - 23228178
SN - 0041-1132
VL - 53
SP - 1798
EP - 1807
JO - Transfusion
JF - Transfusion
IS - 8
ER -
