Evaluation of a novel biphasic calcium phosphate in standardized bone defects: a histologic and histomorphometric study in the mandibles of minipigs

TY - JOUR

T1 - Evaluation of a novel biphasic calcium phosphate in standardized bone defects

T2 - a histologic and histomorphometric study in the mandibles of minipigs

AU - Jensen, Simon Storgård

AU - Yeo, Alvin

AU - Dard, Michel

AU - Hunziker, Ernst

AU - Schenk, Robert

AU - Buser, Daniel

PY - 2007/12

Y1 - 2007/12

N2 - OBJECTIVE: A novel biphasic calcium phosphate (CaP) granulate consisting of hydroxyapatite (HA) and beta-tricalciumphosphate (TCP) was compared with pure HA and pure TCP and with autograft as positive control.MATERIALS AND METHODS: Four standardized bone defects were prepared in both mandibular angles of 16 minipigs and grafted with autogenous bone chips, HA, HA/TCP (60% : 40%), or TCP. Histologic and histomorphometric analysis of bone formation and graft degradation followed healing periods of 2, 4, 8, and 24 weeks.RESULTS: 2 weeks: more bone formation in defects filled with autograft than with the three CaP materials (P<0.05). 4 weeks: bone formation differed significantly (P<0.05) between all four materials (autograft>TCP>HA/TCP>HA). 8 weeks: more bone formation in defects with autograft and TCP than with HA/TCP (P<0.05), and HA/TCP had more bone formation than HA (P<0.05). 24 weeks: no difference in bone formation between the groups. Autograft and TCP resorbed quickly and almost completely over 8 weeks, whereas HA/TCP and HA showed limited degradation over 24 weeks.CONCLUSION: All defects healed with mature lamellar bone and intimate contact between bone and the remaining graft material. The rate of bone formation corresponded to the content of TCP in the CaP materials.

AB - OBJECTIVE: A novel biphasic calcium phosphate (CaP) granulate consisting of hydroxyapatite (HA) and beta-tricalciumphosphate (TCP) was compared with pure HA and pure TCP and with autograft as positive control.MATERIALS AND METHODS: Four standardized bone defects were prepared in both mandibular angles of 16 minipigs and grafted with autogenous bone chips, HA, HA/TCP (60% : 40%), or TCP. Histologic and histomorphometric analysis of bone formation and graft degradation followed healing periods of 2, 4, 8, and 24 weeks.RESULTS: 2 weeks: more bone formation in defects filled with autograft than with the three CaP materials (P<0.05). 4 weeks: bone formation differed significantly (P<0.05) between all four materials (autograft>TCP>HA/TCP>HA). 8 weeks: more bone formation in defects with autograft and TCP than with HA/TCP (P<0.05), and HA/TCP had more bone formation than HA (P<0.05). 24 weeks: no difference in bone formation between the groups. Autograft and TCP resorbed quickly and almost completely over 8 weeks, whereas HA/TCP and HA showed limited degradation over 24 weeks.CONCLUSION: All defects healed with mature lamellar bone and intimate contact between bone and the remaining graft material. The rate of bone formation corresponded to the content of TCP in the CaP materials.

KW - Animals

KW - Biocompatible Materials/administration & dosage

KW - Bone Substitutes/administration & dosage

KW - Bone Transplantation/methods

KW - Calcium Phosphates/administration & dosage

KW - Drug Combinations

KW - Durapatite/administration & dosage

KW - Follow-Up Studies

KW - Mandible/drug effects

KW - Osseointegration/drug effects

KW - Osteogenesis/drug effects

KW - Swine

KW - Swine, Miniature

U2 - 10.1111/j.1600-0501.2007.01417.x

DO - 10.1111/j.1600-0501.2007.01417.x

M3 - Journal article

C2 - 17888014

SN - 0905-7161

VL - 18

SP - 752

EP - 760

JO - Clinical Oral Implants Research

JF - Clinical Oral Implants Research

IS - 6

ER -