Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Miriam Haaser; Kaisa Naelapaa; Keith C Gordon; Michael Pepper; Jukka Rantanen; Clare J Strachan; Philip F Taday; J Axel Zeitler; Thomas Rades

doi:10.1016/j.ejpb.2013.03.019

Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Miriam Haaser, Kaisa Naelapaa, Keith C Gordon, Michael Pepper, Jukka Rantanen, Clare J Strachan, Philip F Taday, J Axel Zeitler, Thomas Rades

15 Citationer (Scopus)

Abstract

In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p

Originalsprog	Engelsk
Tidsskrift	European Journal of Pharmaceutics and Biopharmaceutics
Vol/bind	85
Udgave nummer	3 Pt B
Sider (fra-til)	1095-102
Antal sider	8
ISSN	0939-6411
DOI	https://doi.org/10.1016/j.ejpb.2013.03.019
Status	Udgivet - nov. 2013

Adgang til dokumentet

10.1016/j.ejpb.2013.03.019

Citationsformater

@article{92e832d5ccee40f7ba18374de9503213,

title = "Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging",

abstract = "In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p",

author = "Miriam Haaser and Kaisa Naelapaa and Gordon, {Keith C} and Michael Pepper and Jukka Rantanen and Strachan, {Clare J} and Taday, {Philip F} and Zeitler, {J Axel} and Thomas Rades",

year = "2013",

month = nov,

doi = "10.1016/j.ejpb.2013.03.019",

language = "English",

volume = "85",

pages = "1095--102",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "Elsevier",

number = "3 Pt B",

}

TY - JOUR

T1 - Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

AU - Haaser, Miriam

AU - Naelapaa, Kaisa

AU - Gordon, Keith C

AU - Pepper, Michael

AU - Rantanen, Jukka

AU - Strachan, Clare J

AU - Taday, Philip F

AU - Zeitler, J Axel

AU - Rades, Thomas

PY - 2013/11

Y1 - 2013/11

N2 - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p

AB - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p

U2 - 10.1016/j.ejpb.2013.03.019

DO - 10.1016/j.ejpb.2013.03.019

M3 - Journal article

C2 - 23563103

SN - 0939-6411

VL - 85

SP - 1095

EP - 1102

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 3 Pt B

ER -

Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater