Milman, A., Andorin, A., Postema, P. G., Gourraud, J. B., Sacher, F., Mabo, P., Kim, S. H., Maeda, S., Takahashi, Y., Kamakura, T., Aiba, T., Conte, G., Juang, J. J. M., Leshem, E., Michowitz, Y., Fogelman, R., Hochstadt, A., Mizusawa, Y., Giustetto, C., ... Belhassen, B. (2019). Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome. Heart Rhythm, 16(10), 1468-1474. https://doi.org/10.1016/j.hrthm.2019.07.003
Milman, A, Andorin, A, Postema, PG, Gourraud, JB, Sacher, F, Mabo, P, Kim, SH, Maeda, S, Takahashi, Y, Kamakura, T, Aiba, T, Conte, G, Juang, JJM, Leshem, E, Michowitz, Y, Fogelman, R, Hochstadt, A, Mizusawa, Y, Giustetto, C, Arbelo, E, Huang, Z, Corrado, D, Delise, P, Allocca, G, Takagi, M, Wijeyeratne, YD, Mazzanti, A, Brugada, R, Casado-Arroyo, R, Champagne, J, Calo, L, Sarquella-Brugada, G, Jespersen, CH, Tfelt-Hansen, J, Veltmann, C, Priori, SG, Behr, ER, Yan, GX, Brugada, J, Gaita, F, Wilde, AAM, Brugada, P, Kusano, KF, Hirao, K, Nam, GB, Probst, V & Belhassen, B 2019, 'Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome', Heart Rhythm, bind 16, nr. 10, s. 1468-1474. https://doi.org/10.1016/j.hrthm.2019.07.003
@article{4fea64baa495471c86b5fc4929a9007f,
title = "Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome",
abstract = "Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results: There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion: There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.",
keywords = "Arrhythmic event, Asian, Brugada syndrome, SCN5A mutation, White",
author = "Anat Milman and Antoine Andorin and Postema, {Pieter G.} and Gourraud, {Jean Baptiste} and Frederic Sacher and Philippe Mabo and Kim, {Sung Hwan} and Shingo Maeda and Yoshihide Takahashi and Tsukasa Kamakura and Takeshi Aiba and Giulio Conte and Juang, {Jimmy J.M.} and Eran Leshem and Yoav Michowitz and Rami Fogelman and Aviram Hochstadt and Yuka Mizusawa and Carla Giustetto and Elena Arbelo and Zhengrong Huang and Domenico Corrado and Pietro Delise and Giuseppe Allocca and Masahiko Takagi and Wijeyeratne, {Yanushi D.} and Andrea Mazzanti and Ramon Brugada and Ruben Casado-Arroyo and Jean Champagne and Leonardo Calo and Georgia Sarquella-Brugada and Jespersen, {Camilla H.} and Jacob Tfelt-Hansen and Christian Veltmann and Priori, {Silvia G.} and Behr, {Elijah R.} and Yan, {Gan Xin} and Josep Brugada and Fiorenzo Gaita and Wilde, {Arthur A.M.} and Pedro Brugada and Kusano, {Kengo F.} and Kenzo Hirao and Nam, {Gi Byoung} and Vincent Probst and Bernard Belhassen",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.hrthm.2019.07.003",
language = "English",
volume = "16",
pages = "1468--1474",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "10",
}
TY - JOUR
T1 - Ethnic differences in patients with Brugada syndrome and arrhythmic events
T2 - New insights from Survey on Arrhythmic Events in Brugada Syndrome
AU - Milman, Anat
AU - Andorin, Antoine
AU - Postema, Pieter G.
AU - Gourraud, Jean Baptiste
AU - Sacher, Frederic
AU - Mabo, Philippe
AU - Kim, Sung Hwan
AU - Maeda, Shingo
AU - Takahashi, Yoshihide
AU - Kamakura, Tsukasa
AU - Aiba, Takeshi
AU - Conte, Giulio
AU - Juang, Jimmy J.M.
AU - Leshem, Eran
AU - Michowitz, Yoav
AU - Fogelman, Rami
AU - Hochstadt, Aviram
AU - Mizusawa, Yuka
AU - Giustetto, Carla
AU - Arbelo, Elena
AU - Huang, Zhengrong
AU - Corrado, Domenico
AU - Delise, Pietro
AU - Allocca, Giuseppe
AU - Takagi, Masahiko
AU - Wijeyeratne, Yanushi D.
AU - Mazzanti, Andrea
AU - Brugada, Ramon
AU - Casado-Arroyo, Ruben
AU - Champagne, Jean
AU - Calo, Leonardo
AU - Sarquella-Brugada, Georgia
AU - Jespersen, Camilla H.
AU - Tfelt-Hansen, Jacob
AU - Veltmann, Christian
AU - Priori, Silvia G.
AU - Behr, Elijah R.
AU - Yan, Gan Xin
AU - Brugada, Josep
AU - Gaita, Fiorenzo
AU - Wilde, Arthur A.M.
AU - Brugada, Pedro
AU - Kusano, Kengo F.
AU - Hirao, Kenzo
AU - Nam, Gi Byoung
AU - Probst, Vincent
AU - Belhassen, Bernard
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results: There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion: There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.
AB - Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results: There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion: There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.
KW - Arrhythmic event
KW - Asian
KW - Brugada syndrome
KW - SCN5A mutation
KW - White
UR - http://www.scopus.com/inward/record.url?scp=85072284665&partnerID=8YFLogxK
U2 - 10.1016/j.hrthm.2019.07.003
DO - 10.1016/j.hrthm.2019.07.003
M3 - Journal article
C2 - 31284050
AN - SCOPUS:85072284665
SN - 1547-5271
VL - 16
SP - 1468
EP - 1474
JO - Heart Rhythm
JF - Heart Rhythm
IS - 10
ER -
