Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography

TY - JOUR

T1 - Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography

AU - Henriksen, Otto Mølby

AU - Larsson, Henrik B W

AU - Hansen, Adam E

AU - Grüner, Julie Marie

AU - Law, Ian

AU - Rostrup, Egill

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2012/6

Y1 - 2012/6

N2 - Purpose: To investigate the within and between subject variability of quantitative cerebral blood flow (CBF) measurements in normal subjects using various MRI techniques and positron emission tomography (PET). Materials and Methods: Repeated CBF measurements were performed in 17 healthy, young subjects using three different MRI techniques: arterial spin labeling (ASL), dynamic contrast enhanced T1 weighted perfusion MRI (DCE) and phase contrast mapping (PCM). All MRI measurements were performed within the same session. In 10 of the subjects repeated CBF measurements by 15O labeled water PET had recently been performed. A mixed linear model was used to estimate between subject (CVbetw) and within subject (CVwith) coefficients of variation. Results: Mean global CBF, CVbetw and CVwith using each of the four methods were for PCM 65.2 mL/100 g/min, 17.4% and 7.4%, for ASL 37.1 mL/100 g/min, 16.2% and 4.8%, for DCE 43.0 mL/100 g/min, 20.0%, 15.1% and for PET 41.9 mL/100 g/min, 16.5% and 11.9%, respectively. Only for DCE and PCM a significant positive correlation between measurements was demonstrated. Conclusion: These findings confirm large between subject variability in CBF measurements, but suggest also that in healthy subjects a subject-method interaction is a possible source of between subject variability and of method differences.

AB - Purpose: To investigate the within and between subject variability of quantitative cerebral blood flow (CBF) measurements in normal subjects using various MRI techniques and positron emission tomography (PET). Materials and Methods: Repeated CBF measurements were performed in 17 healthy, young subjects using three different MRI techniques: arterial spin labeling (ASL), dynamic contrast enhanced T1 weighted perfusion MRI (DCE) and phase contrast mapping (PCM). All MRI measurements were performed within the same session. In 10 of the subjects repeated CBF measurements by 15O labeled water PET had recently been performed. A mixed linear model was used to estimate between subject (CVbetw) and within subject (CVwith) coefficients of variation. Results: Mean global CBF, CVbetw and CVwith using each of the four methods were for PCM 65.2 mL/100 g/min, 17.4% and 7.4%, for ASL 37.1 mL/100 g/min, 16.2% and 4.8%, for DCE 43.0 mL/100 g/min, 20.0%, 15.1% and for PET 41.9 mL/100 g/min, 16.5% and 11.9%, respectively. Only for DCE and PCM a significant positive correlation between measurements was demonstrated. Conclusion: These findings confirm large between subject variability in CBF measurements, but suggest also that in healthy subjects a subject-method interaction is a possible source of between subject variability and of method differences.

U2 - 10.1002/jmri.23579

DO - 10.1002/jmri.23579

M3 - Journal article

C2 - 22246715

SN - 1053-1807

VL - 35

SP - 1290

EP - 1299

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 6

ER -