Establishment and functions of DNA methylation in the germline

Kathleen Stewart-Morgan; Lenka Veselovska; Gavin Kelsey

doi:10.2217/epi-2016-0056

Establishment and functions of DNA methylation in the germline

Kathleen Stewart-Morgan, Lenka Veselovska, Gavin Kelsey^*

^*Corresponding author af dette arbejde

72 Citationer (Scopus)

75 Downloads (Pure)

Abstract

Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.

Originalsprog	Engelsk
Tidsskrift	Epigenomics
Vol/bind	8
Udgave nummer	10
Sider (fra-til)	1399-1413
Antal sider	15
ISSN	1750-1911
DOI	https://doi.org/10.2217/epi-2016-0056
Status	Udgivet - 2016

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10.2217/epi-2016-0056Licens: CC BY-NC-ND

Establishment and functions of DNA methylation in the germlineForlagets udgivne version, 3,54 MBLicens: CC BY

Citationsformater

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AB - Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.

KW - DNA methylation

KW - embryo

KW - imprinting

KW - oogenesis

KW - spermatogenesis

KW - transgenerational inheritance

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Establishment and functions of DNA methylation in the germline

Abstract

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