Epigenome Remodeling in Cholangiocarcinoma

Colm J O'Rourke; Juan Lafuente-Barquero; Jesper B Andersen

doi:10.1016/j.trecan.2019.05.002

Epigenome Remodeling in Cholangiocarcinoma

Colm J O'Rourke, Juan Lafuente-Barquero, Jesper B Andersen

8 Citationer (Scopus)

Abstract

Cholangiocarcinoma (CCA) comprises a heterogeneous collection of malignancies arising within the biliary tract, characterized by late diagnosis, innate chemoresistance, and abysmal prognosis. Sequencing data have uncovered recurrent mutations in diverse epigenetic regulators, implicating epigenetic destabilization at the root of these tumors. However, few studies have characterized biliary tumor epigenomes. In this Opinion article, we argue that an epigenome-oriented approach to CCA could establish diverse interconnections between many key aspects of research on this disease, including molecular heterogeneity, diverse cells of origin, and prominent tumor microenvironments. Moreover, we discuss plausible causes of epigenome dysregulation in biliary tumors, including genetic, epigenetic, metabolic, microenvironmental, and physiological factors. Lastly, we assess the translational potential of epigenomics in CCA to uncover robust biomarkers and therapeutic opportunities for this growing group of patients with limited treatment options.

Originalsprog	Engelsk
Tidsskrift	Trends in Cancer
Vol/bind	5
Udgave nummer	6
Sider (fra-til)	335-350
Antal sider	16
ISSN	2405-8033
DOI	https://doi.org/10.1016/j.trecan.2019.05.002
Status	Udgivet - jun. 2019

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10.1016/j.trecan.2019.05.002

Citationsformater

@article{026e02e2ad684455a9c747d6e8941c81,

title = "Epigenome Remodeling in Cholangiocarcinoma",

abstract = "Cholangiocarcinoma (CCA) comprises a heterogeneous collection of malignancies arising within the biliary tract, characterized by late diagnosis, innate chemoresistance, and abysmal prognosis. Sequencing data have uncovered recurrent mutations in diverse epigenetic regulators, implicating epigenetic destabilization at the root of these tumors. However, few studies have characterized biliary tumor epigenomes. In this Opinion article, we argue that an epigenome-oriented approach to CCA could establish diverse interconnections between many key aspects of research on this disease, including molecular heterogeneity, diverse cells of origin, and prominent tumor microenvironments. Moreover, we discuss plausible causes of epigenome dysregulation in biliary tumors, including genetic, epigenetic, metabolic, microenvironmental, and physiological factors. Lastly, we assess the translational potential of epigenomics in CCA to uncover robust biomarkers and therapeutic opportunities for this growing group of patients with limited treatment options.",

author = "O'Rourke, {Colm J} and Juan Lafuente-Barquero and Andersen, {Jesper B}",

year = "2019",

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doi = "10.1016/j.trecan.2019.05.002",

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TY - JOUR

T1 - Epigenome Remodeling in Cholangiocarcinoma

AU - O'Rourke, Colm J

AU - Lafuente-Barquero, Juan

AU - Andersen, Jesper B

PY - 2019/6

Y1 - 2019/6

N2 - Cholangiocarcinoma (CCA) comprises a heterogeneous collection of malignancies arising within the biliary tract, characterized by late diagnosis, innate chemoresistance, and abysmal prognosis. Sequencing data have uncovered recurrent mutations in diverse epigenetic regulators, implicating epigenetic destabilization at the root of these tumors. However, few studies have characterized biliary tumor epigenomes. In this Opinion article, we argue that an epigenome-oriented approach to CCA could establish diverse interconnections between many key aspects of research on this disease, including molecular heterogeneity, diverse cells of origin, and prominent tumor microenvironments. Moreover, we discuss plausible causes of epigenome dysregulation in biliary tumors, including genetic, epigenetic, metabolic, microenvironmental, and physiological factors. Lastly, we assess the translational potential of epigenomics in CCA to uncover robust biomarkers and therapeutic opportunities for this growing group of patients with limited treatment options.

AB - Cholangiocarcinoma (CCA) comprises a heterogeneous collection of malignancies arising within the biliary tract, characterized by late diagnosis, innate chemoresistance, and abysmal prognosis. Sequencing data have uncovered recurrent mutations in diverse epigenetic regulators, implicating epigenetic destabilization at the root of these tumors. However, few studies have characterized biliary tumor epigenomes. In this Opinion article, we argue that an epigenome-oriented approach to CCA could establish diverse interconnections between many key aspects of research on this disease, including molecular heterogeneity, diverse cells of origin, and prominent tumor microenvironments. Moreover, we discuss plausible causes of epigenome dysregulation in biliary tumors, including genetic, epigenetic, metabolic, microenvironmental, and physiological factors. Lastly, we assess the translational potential of epigenomics in CCA to uncover robust biomarkers and therapeutic opportunities for this growing group of patients with limited treatment options.

U2 - 10.1016/j.trecan.2019.05.002

DO - 10.1016/j.trecan.2019.05.002

M3 - Review

C2 - 31208696

SN - 2405-8033

VL - 5

SP - 335

EP - 350

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -

Epigenome Remodeling in Cholangiocarcinoma

Abstract

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