Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice

TY - JOUR

T1 - Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice

AU - Hertz, Frederik Boetius

AU - Schønning, Kristian

AU - Rasmussen, Steen Christian

AU - Littauer, Pia

AU - Knudsen, Jenny Dahl

AU - Løbner-Olesen, Anders

AU - Frimodt-Møller, Niels

PY - 2016

Y1 - 2016

N2 - The purpose of the study was to evaluate how use of antibiotics precedes the presence of ESBLproducing E.coli in general practice. The authors performed a triple-case-control study where three case groups were individually compared to a single control group of uninfected individuals. Urine samples were prospectively collected and retrospective statistical analyses were done. This study included 98 cases with urinary tract infection (UTI) caused by ESBL-producing E. coli, 174 with antibiotic-resistant (non-ESBL) E. coli, 177 with susceptible E. coli and 200 with culture negative urine samples. Case groups had significantly higher use of antibiotics than the control group within 30 days before infection (p<0.0001). The ESBL group had significantly more hospital admissions than the other case groups (p<0.05). Hospital admission was an independent risk factor for community onset UTI by ESBL-producing E. coli. Exposure to antibiotics was a risk factor for UTI with E. coli, while prior antibiotic usage was not an indisputable predictor for infection with ESBLproducing E.coli in general practice.

AB - The purpose of the study was to evaluate how use of antibiotics precedes the presence of ESBLproducing E.coli in general practice. The authors performed a triple-case-control study where three case groups were individually compared to a single control group of uninfected individuals. Urine samples were prospectively collected and retrospective statistical analyses were done. This study included 98 cases with urinary tract infection (UTI) caused by ESBL-producing E. coli, 174 with antibiotic-resistant (non-ESBL) E. coli, 177 with susceptible E. coli and 200 with culture negative urine samples. Case groups had significantly higher use of antibiotics than the control group within 30 days before infection (p<0.0001). The ESBL group had significantly more hospital admissions than the other case groups (p<0.05). Hospital admission was an independent risk factor for community onset UTI by ESBL-producing E. coli. Exposure to antibiotics was a risk factor for UTI with E. coli, while prior antibiotic usage was not an indisputable predictor for infection with ESBLproducing E.coli in general practice.

U2 - 10.3109/23744235.2015.1103895

DO - 10.3109/23744235.2015.1103895

M3 - Journal article

C2 - 26523346

SN - 2374-4235

VL - 48

SP - 241

EP - 245

JO - Infectious Diseases

JF - Infectious Diseases

IS - 3

ER -