Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

Regitse H. Christensen; Bernt J. Von Scholten; Christian S. Hansen; Sarah E. Heywood; Jaya B. Rosenmeier; Ulrik B. Andersen; Peter Hovind; Henrik Reinhard; Hans Henrik Parving; Bente K. Pedersen; Marit E. Jørgensen; Peter K. Jacobsen; Peter Rossing

doi:10.1177/2047487317717820

Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

Regitse H. Christensen^*, Bernt J. Von Scholten, Christian S. Hansen, Sarah E. Heywood, Jaya B. Rosenmeier, Ulrik B. Andersen, Peter Hovind, Henrik Reinhard, Hans Henrik Parving, Bente K. Pedersen, Marit E. Jørgensen, Peter K. Jacobsen, Peter Rossing

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

23 Citationer (Scopus)

Abstract

Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality. Coronary artery calcium, carotid intima media thickness and inflammatory markers were measured at baseline. Cardiac adipose tissue was investigated as continuous and binary variable. Analyses were performed unadjusted (model 1), and adjusted for age, sex (model 2), body mass index, low-density lipoprotein cholesterol, smoking, glycated haemoglobin, and systolic blood pressure (model 3). Results Patients were followed-up after 6.1 years for non-fatal cardiovascular disease (n = 29) or mortality (n = 23). Cardiac adipose tissue (p = 0.049) and epicardial adipose tissue (p = 0.029) were associated with cardiovascular disease and mortality in model 1. When split by the median, patients with high cardiac adipose tissue had a higher risk of cardiovascular disease and mortality than patients with low cardiac adipose tissue in unadjusted (hazard ratio 1.9, confidence interval: 1.1; 3.4, p = 0.027) and adjusted (hazard ratio 2.0, confidence interval: 1.1; 3.7, p = 0.017) models. Cardiac adipose tissue (p = 0.033) was associated with baseline coronary artery calcium (model 1) and interleukin-8 (models 1-3, all p < 0.039). Conclusions In type 2 diabetes patients without coronary artery disease, high cardiac adipose tissue levels were associated with increased risk of incident cardiovascular disease or all-cause mortality even after accounting for traditional cardiovascular disease risk factors. High cardiac adipose tissue amounts were associated with subclinical atherosclerosis (coronary artery calcium) and with the pro-atherogenic inflammatory marker interleukin-8.

Originalsprog	Engelsk
Tidsskrift	European Journal of Preventive Cardiology
Vol/bind	24
Udgave nummer	14
Sider (fra-til)	1517-1524
ISSN	2047-4873
DOI	https://doi.org/10.1177/2047487317717820
Status	Udgivet - 2017

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Christensen, R. H., Von Scholten, B. J., Hansen, C. S., Heywood, S. E., Rosenmeier, J. B., Andersen, U. B., Hovind, P., Reinhard, H., Parving, H. H., Pedersen, B. K., Jørgensen, M. E., Jacobsen, P. K., & Rossing, P. (2017). Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate. European Journal of Preventive Cardiology, 24(14), 1517-1524. https://doi.org/10.1177/2047487317717820

Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate. / Christensen, Regitse H.; Von Scholten, Bernt J.; Hansen, Christian S. et al.
I: European Journal of Preventive Cardiology, Bind 24, Nr. 14, 2017, s. 1517-1524.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Christensen, RH, Von Scholten, BJ, Hansen, CS, Heywood, SE, Rosenmeier, JB, Andersen, UB, Hovind, P, Reinhard, H, Parving, HH, Pedersen, BK, Jørgensen, ME, Jacobsen, PK & Rossing, P 2017, 'Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate', European Journal of Preventive Cardiology, bind 24, nr. 14, s. 1517-1524. https://doi.org/10.1177/2047487317717820

@article{294e8d00364d4b94a1268445e79d5ef1,

title = "Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate",

abstract = "Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality. Coronary artery calcium, carotid intima media thickness and inflammatory markers were measured at baseline. Cardiac adipose tissue was investigated as continuous and binary variable. Analyses were performed unadjusted (model 1), and adjusted for age, sex (model 2), body mass index, low-density lipoprotein cholesterol, smoking, glycated haemoglobin, and systolic blood pressure (model 3). Results Patients were followed-up after 6.1 years for non-fatal cardiovascular disease (n = 29) or mortality (n = 23). Cardiac adipose tissue (p = 0.049) and epicardial adipose tissue (p = 0.029) were associated with cardiovascular disease and mortality in model 1. When split by the median, patients with high cardiac adipose tissue had a higher risk of cardiovascular disease and mortality than patients with low cardiac adipose tissue in unadjusted (hazard ratio 1.9, confidence interval: 1.1; 3.4, p = 0.027) and adjusted (hazard ratio 2.0, confidence interval: 1.1; 3.7, p = 0.017) models. Cardiac adipose tissue (p = 0.033) was associated with baseline coronary artery calcium (model 1) and interleukin-8 (models 1-3, all p < 0.039). Conclusions In type 2 diabetes patients without coronary artery disease, high cardiac adipose tissue levels were associated with increased risk of incident cardiovascular disease or all-cause mortality even after accounting for traditional cardiovascular disease risk factors. High cardiac adipose tissue amounts were associated with subclinical atherosclerosis (coronary artery calcium) and with the pro-atherogenic inflammatory marker interleukin-8.",

keywords = "cardiovascular disease, coronary artery calcium, epicardial fat, pericardial fat, Type 2 diabetes",

author = "Christensen, {Regitse H.} and {Von Scholten}, {Bernt J.} and Hansen, {Christian S.} and Heywood, {Sarah E.} and Rosenmeier, {Jaya B.} and Andersen, {Ulrik B.} and Peter Hovind and Henrik Reinhard and Parving, {Hans Henrik} and Pedersen, {Bente K.} and J{\o}rgensen, {Marit E.} and Jacobsen, {Peter K.} and Peter Rossing",

year = "2017",

doi = "10.1177/2047487317717820",

language = "English",

volume = "24",

pages = "1517--1524",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "SAGE Publications",

number = "14",

}

TY - JOUR

T1 - Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

AU - Christensen, Regitse H.

AU - Von Scholten, Bernt J.

AU - Hansen, Christian S.

AU - Heywood, Sarah E.

AU - Rosenmeier, Jaya B.

AU - Andersen, Ulrik B.

AU - Hovind, Peter

AU - Reinhard, Henrik

AU - Parving, Hans Henrik

AU - Pedersen, Bente K.

AU - Jørgensen, Marit E.

AU - Jacobsen, Peter K.

AU - Rossing, Peter

PY - 2017

Y1 - 2017

N2 - Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality. Coronary artery calcium, carotid intima media thickness and inflammatory markers were measured at baseline. Cardiac adipose tissue was investigated as continuous and binary variable. Analyses were performed unadjusted (model 1), and adjusted for age, sex (model 2), body mass index, low-density lipoprotein cholesterol, smoking, glycated haemoglobin, and systolic blood pressure (model 3). Results Patients were followed-up after 6.1 years for non-fatal cardiovascular disease (n = 29) or mortality (n = 23). Cardiac adipose tissue (p = 0.049) and epicardial adipose tissue (p = 0.029) were associated with cardiovascular disease and mortality in model 1. When split by the median, patients with high cardiac adipose tissue had a higher risk of cardiovascular disease and mortality than patients with low cardiac adipose tissue in unadjusted (hazard ratio 1.9, confidence interval: 1.1; 3.4, p = 0.027) and adjusted (hazard ratio 2.0, confidence interval: 1.1; 3.7, p = 0.017) models. Cardiac adipose tissue (p = 0.033) was associated with baseline coronary artery calcium (model 1) and interleukin-8 (models 1-3, all p < 0.039). Conclusions In type 2 diabetes patients without coronary artery disease, high cardiac adipose tissue levels were associated with increased risk of incident cardiovascular disease or all-cause mortality even after accounting for traditional cardiovascular disease risk factors. High cardiac adipose tissue amounts were associated with subclinical atherosclerosis (coronary artery calcium) and with the pro-atherogenic inflammatory marker interleukin-8.

AB - Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality. Coronary artery calcium, carotid intima media thickness and inflammatory markers were measured at baseline. Cardiac adipose tissue was investigated as continuous and binary variable. Analyses were performed unadjusted (model 1), and adjusted for age, sex (model 2), body mass index, low-density lipoprotein cholesterol, smoking, glycated haemoglobin, and systolic blood pressure (model 3). Results Patients were followed-up after 6.1 years for non-fatal cardiovascular disease (n = 29) or mortality (n = 23). Cardiac adipose tissue (p = 0.049) and epicardial adipose tissue (p = 0.029) were associated with cardiovascular disease and mortality in model 1. When split by the median, patients with high cardiac adipose tissue had a higher risk of cardiovascular disease and mortality than patients with low cardiac adipose tissue in unadjusted (hazard ratio 1.9, confidence interval: 1.1; 3.4, p = 0.027) and adjusted (hazard ratio 2.0, confidence interval: 1.1; 3.7, p = 0.017) models. Cardiac adipose tissue (p = 0.033) was associated with baseline coronary artery calcium (model 1) and interleukin-8 (models 1-3, all p < 0.039). Conclusions In type 2 diabetes patients without coronary artery disease, high cardiac adipose tissue levels were associated with increased risk of incident cardiovascular disease or all-cause mortality even after accounting for traditional cardiovascular disease risk factors. High cardiac adipose tissue amounts were associated with subclinical atherosclerosis (coronary artery calcium) and with the pro-atherogenic inflammatory marker interleukin-8.

KW - cardiovascular disease

KW - coronary artery calcium

KW - epicardial fat

KW - pericardial fat

KW - Type 2 diabetes

U2 - 10.1177/2047487317717820

DO - 10.1177/2047487317717820

M3 - Journal article

C2 - 28650207

AN - SCOPUS:85029296507

SN - 2047-4873

VL - 24

SP - 1517

EP - 1524

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

IS - 14

ER -

Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate

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