Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study

R B Postuma; J Y Montplaisir; A Pelletier; Y Dauvilliers; W Oertel; A Iranzo; L Ferini-Strambi; I Arnulf; B Hogl; R Manni; T Miyamoto; G Mayer; K Stiasny-Kolster; M Puligheddu; Y Ju; P Jennum; K Sonka; J Santamaria; M L Fantini; M Zucconi; S Leu-Semenescu; B Frauscher; M Terzaghi; M Miyamoto; M M Unger; V Cochen De Cock; C Wolfson

doi:10.1212/WNL.0b013e31825dd383

Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study

R B Postuma, J Y Montplaisir, A Pelletier, Y Dauvilliers, W Oertel, A Iranzo, L Ferini-Strambi, I Arnulf, B Hogl, R Manni, T Miyamoto, G Mayer, K Stiasny-Kolster, M Puligheddu, Y Ju, P Jennum, K Sonka, J Santamaria, M L Fantini, M ZucconiS Leu-Semenescu, B Frauscher, M Terzaghi, M Miyamoto, M M Unger, V Cochen De Cock, C Wolfson

73 Citationer (Scopus)

Abstract

Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

Originalsprog	Engelsk
Tidsskrift	Neurology
Vol/bind	79
Udgave nummer	5
Sider (fra-til)	428-34
Antal sider	7
ISSN	0028-3878
DOI	https://doi.org/10.1212/WNL.0b013e31825dd383
Status	Udgivet - 31 jul. 2012

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10.1212/WNL.0b013e31825dd383

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Postuma, R. B., Montplaisir, J. Y., Pelletier, A., Dauvilliers, Y., Oertel, W., Iranzo, A., Ferini-Strambi, L., Arnulf, I., Hogl, B., Manni, R., Miyamoto, T., Mayer, G., Stiasny-Kolster, K., Puligheddu, M., Ju, Y., Jennum, P., Sonka, K., Santamaria, J., Fantini, M. L., ... Wolfson, C. (2012). Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. Neurology, 79(5), 428-34. https://doi.org/10.1212/WNL.0b013e31825dd383

Postuma, RB, Montplaisir, JY, Pelletier, A, Dauvilliers, Y, Oertel, W, Iranzo, A, Ferini-Strambi, L, Arnulf, I, Hogl, B, Manni, R, Miyamoto, T, Mayer, G, Stiasny-Kolster, K, Puligheddu, M, Ju, Y, Jennum, P, Sonka, K, Santamaria, J, Fantini, ML, Zucconi, M, Leu-Semenescu, S, Frauscher, B, Terzaghi, M, Miyamoto, M, Unger, MM, Cochen De Cock, V & Wolfson, C 2012, 'Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study', Neurology, bind 79, nr. 5, s. 428-34. https://doi.org/10.1212/WNL.0b013e31825dd383

@article{d4becc10bb664311b151d21c4eaf8013,

title = "Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study",

abstract = "Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.",

author = "Postuma, {R B} and Montplaisir, {J Y} and A Pelletier and Y Dauvilliers and W Oertel and A Iranzo and L Ferini-Strambi and I Arnulf and B Hogl and R Manni and T Miyamoto and G Mayer and K Stiasny-Kolster and M Puligheddu and Y Ju and P Jennum and K Sonka and J Santamaria and Fantini, {M L} and M Zucconi and S Leu-Semenescu and B Frauscher and M Terzaghi and M Miyamoto and Unger, {M M} and {Cochen De Cock}, V and C Wolfson",

year = "2012",

month = jul,

day = "31",

doi = "10.1212/WNL.0b013e31825dd383",

language = "English",

volume = "79",

pages = "428--34",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams & Wilkins",

number = "5",

}

TY - JOUR

T1 - Environmental risk factors for REM sleep behavior disorder

T2 - a multicenter case-control study

AU - Postuma, R B

AU - Montplaisir, J Y

AU - Pelletier, A

AU - Dauvilliers, Y

AU - Oertel, W

AU - Iranzo, A

AU - Ferini-Strambi, L

AU - Arnulf, I

AU - Hogl, B

AU - Manni, R

AU - Miyamoto, T

AU - Mayer, G

AU - Stiasny-Kolster, K

AU - Puligheddu, M

AU - Ju, Y

AU - Jennum, P

AU - Sonka, K

AU - Santamaria, J

AU - Fantini, M L

AU - Zucconi, M

AU - Leu-Semenescu, S

AU - Frauscher, B

AU - Terzaghi, M

AU - Miyamoto, M

AU - Unger, M M

AU - Cochen De Cock, V

AU - Wolfson, C

PY - 2012/7/31

Y1 - 2012/7/31

N2 - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

AB - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

U2 - 10.1212/WNL.0b013e31825dd383

DO - 10.1212/WNL.0b013e31825dd383

M3 - Journal article

C2 - 22744670

SN - 0028-3878

VL - 79

SP - 428

EP - 434

JO - Neurology

JF - Neurology

IS - 5

ER -

Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study

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