Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

TY - JOUR

T1 - Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

AU - Silva, Guilherme Testa

AU - Le Bé, Jean-Vincent

AU - Riachi, Imad

AU - Rinaldi, Tania

AU - Markram, Kamila

AU - Markram, Henry

AU - Rinaldi Barkat, Tania

PY - 2009

Y1 - 2009

N2 - A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyperplastic due to over-expression of NMDA receptors. These changes were restricted to the dimensions of a minicolumn (

AB - A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyperplastic due to over-expression of NMDA receptors. These changes were restricted to the dimensions of a minicolumn (

U2 - 10.3389/neuro.19.001.2009

DO - 10.3389/neuro.19.001.2009

M3 - Journal article

C2 - 21423407

SN - 1663-3563

VL - 1

SP - 1

JO - Frontiers in Synaptic Neuroscience

JF - Frontiers in Synaptic Neuroscience

ER -