Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition

TY - CHAP

T1 - Engineering Barriers to Infection by Undermining Pathogen Effector Function or by Gaining Effector Recognition

AU - Ahmed, Ali Abdurehim

AU - Mclellan, Hazel

AU - Aguilar, Geziel Barbosa

AU - Hein, Ingo

AU - Thordal-Christensen, Hans

AU - Birch, Paul R.J.

PY - 2016

Y1 - 2016

N2 - This chapter reviews potential disease control strategies by employing the current understanding of Pathogen-Associated Molecular Patterns (PAMPs) and their receptors, as well as effectors and their targets. It discusses how effectoromics, i.e. surveying which, and to what level, effectors are expressed at a pathogen population level, can help to select the most useful and durable R genes. Plant immunity can be boosted by overexpressing a Pattern-Recognition Receptor (PRR) in a closely- or more-distantly related plant to strengthen PAMP-Triggered Immunity (PTI). An interesting aspect of NB-LRR transcript regulation that involves small RNAs is currently emerging and could potentially be explored in the search for more durable and/or broad-spectrum pathogen resistance. The chapter suggests ways that can be used to undermine effector function and be exploited to engineer resistant plants in the future. It further illustrates how a mechanistic understanding of a pathogen's stealth strategies may allow new approaches to engineer resistance.

AB - This chapter reviews potential disease control strategies by employing the current understanding of Pathogen-Associated Molecular Patterns (PAMPs) and their receptors, as well as effectors and their targets. It discusses how effectoromics, i.e. surveying which, and to what level, effectors are expressed at a pathogen population level, can help to select the most useful and durable R genes. Plant immunity can be boosted by overexpressing a Pattern-Recognition Receptor (PRR) in a closely- or more-distantly related plant to strengthen PAMP-Triggered Immunity (PTI). An interesting aspect of NB-LRR transcript regulation that involves small RNAs is currently emerging and could potentially be explored in the search for more durable and/or broad-spectrum pathogen resistance. The chapter suggests ways that can be used to undermine effector function and be exploited to engineer resistant plants in the future. It further illustrates how a mechanistic understanding of a pathogen's stealth strategies may allow new approaches to engineer resistance.

KW - Effector recognition

KW - Effectoromics

KW - Engineering resistance

KW - NB-LRR-type resistance proteins

KW - PAMP-triggered immunity

KW - Pathogen effector function

KW - Pattern recognition receptor

KW - Plant defence

U2 - 10.1002/9781118867716.ch2

DO - 10.1002/9781118867716.ch2

M3 - Book chapter

AN - SCOPUS:85017660801

SN - 9781118867761

SP - 23

EP - 50

BT - Plant Pathogen Resistance Biotechnology

A2 - Collinge, David B.

PB - Wiley-Blackwell

ER -