Endurance training in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid; Kamilla Winding; Anders Rinnov; Thomas Dejgaard; Carsten Thomsen; Peter Iversen; Klaus Brasso; Kari J Mikines; Gerrit van Hall; Birgitte Lindegaard; Thomas Pj Solomon; Bente Klarlund Pedersen

doi:10.1530/ERC-12-0393

Endurance training in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid, Kamilla Winding, Anders Rinnov, Thomas Dejgaard, Carsten Thomsen, Peter Iversen, Klaus Brasso, Kari J Mikines, Gerrit van Hall, Birgitte Lindegaard, Thomas Pj Solomon, Bente Klarlund Pedersen

Institut for Klinisk Medicin

22 Citationer (Scopus)

Abstract

Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigates if endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and 10 healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy x-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistics: Two-way ANOVA. Endurance training increased VO2max (ml(O2)/min/kg) by 11% and 13% in patients and controls, respectively (p

Originalsprog	Engelsk
Tidsskrift	Endocrine - Related Cancer
ISSN	1351-0088
DOI	https://doi.org/10.1530/ERC-12-0393
Status	Udgivet - 6 jun. 2013

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10.1530/ERC-12-0393

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title = "Endurance training in prostate cancer patients treated with androgen deprivation therapy",

abstract = "Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigates if endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and 10 healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy x-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistics: Two-way ANOVA. Endurance training increased VO2max (ml(O2)/min/kg) by 11% and 13% in patients and controls, respectively (p",

author = "Thine Hvid and Kamilla Winding and Anders Rinnov and Thomas Dejgaard and Carsten Thomsen and Peter Iversen and Klaus Brasso and Mikines, {Kari J} and {van Hall}, Gerrit and Birgitte Lindegaard and Solomon, {Thomas Pj} and Pedersen, {Bente Klarlund}",

year = "2013",

month = jun,

day = "6",

doi = "10.1530/ERC-12-0393",

language = "English",

journal = "Endocrine - Related Cancer",

issn = "1351-0088",

publisher = "BioScientifica Ltd.",

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TY - JOUR

T1 - Endurance training in prostate cancer patients treated with androgen deprivation therapy

AU - Hvid, Thine

AU - Winding, Kamilla

AU - Rinnov, Anders

AU - Dejgaard, Thomas

AU - Thomsen, Carsten

AU - Iversen, Peter

AU - Brasso, Klaus

AU - Mikines, Kari J

AU - van Hall, Gerrit

AU - Lindegaard, Birgitte

AU - Solomon, Thomas Pj

AU - Pedersen, Bente Klarlund

PY - 2013/6/6

Y1 - 2013/6/6

N2 - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigates if endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and 10 healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy x-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistics: Two-way ANOVA. Endurance training increased VO2max (ml(O2)/min/kg) by 11% and 13% in patients and controls, respectively (p

AB - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigates if endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and 10 healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy x-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistics: Two-way ANOVA. Endurance training increased VO2max (ml(O2)/min/kg) by 11% and 13% in patients and controls, respectively (p

U2 - 10.1530/ERC-12-0393

DO - 10.1530/ERC-12-0393

M3 - Journal article

C2 - 23744766

SN - 1351-0088

JO - Endocrine - Related Cancer

JF - Endocrine - Related Cancer

ER -

Endurance training in prostate cancer patients treated with androgen deprivation therapy

Abstract

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