Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid; Kamilla Winding; Anders Rinnov; Thomas Engel Dejgaard; Carsten Thomsen; Peter Iversen; Klaus Brasso; Kari J Mikines; Gerrit van Hall; Birgitte Lindegaard; Thomas Solomon; Bente K Pedersen

doi:10.1530/erc-12-0393

Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Thine Hvid, Kamilla Winding, Anders Rinnov, Thomas Engel Dejgaard, Carsten Thomsen, Peter Iversen, Klaus Brasso, Kari J Mikines, Gerrit van Hall, Birgitte Lindegaard, Thomas Solomon, Bente K Pedersen

22 Citationer (Scopus)

Abstract

Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P

Originalsprog	Engelsk
Tidsskrift	Endocrine - Related Cancer
Vol/bind	20
Udgave nummer	5
Sider (fra-til)	621-32
Antal sider	12
ISSN	1351-0088
DOI	https://doi.org/10.1530/erc-12-0393
Status	Udgivet - okt. 2013

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10.1530/erc-12-0393

https://erc.bioscientifica.com/downloadpdf/journals/erc/20/5/621.pdf

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Hvid, T., Winding, K., Rinnov, A., Dejgaard, T. E., Thomsen, C., Iversen, P., Brasso, K., Mikines, K. J., van Hall, G., Lindegaard, B., Solomon, T., & Pedersen, B. K. (2013). Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy. Endocrine - Related Cancer, 20(5), 621-32. https://doi.org/10.1530/erc-12-0393

Hvid, T, Winding, K, Rinnov, A, Dejgaard, TE, Thomsen, C, Iversen, P, Brasso, K, Mikines, KJ, van Hall, G, Lindegaard, B, Solomon, T & Pedersen, BK 2013, 'Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy', Endocrine - Related Cancer, bind 20, nr. 5, s. 621-32. https://doi.org/10.1530/erc-12-0393

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title = "Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy",

abstract = "Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P",

author = "Thine Hvid and Kamilla Winding and Anders Rinnov and Dejgaard, {Thomas Engel} and Carsten Thomsen and Peter Iversen and Klaus Brasso and Mikines, {Kari J} and {van Hall}, Gerrit and Birgitte Lindegaard and Thomas Solomon and Pedersen, {Bente K}",

year = "2013",

month = oct,

doi = "10.1530/erc-12-0393",

language = "English",

volume = "20",

pages = "621--32",

journal = "Endocrine - Related Cancer",

issn = "1351-0088",

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TY - JOUR

T1 - Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

AU - Hvid, Thine

AU - Winding, Kamilla

AU - Rinnov, Anders

AU - Dejgaard, Thomas Engel

AU - Thomsen, Carsten

AU - Iversen, Peter

AU - Brasso, Klaus

AU - Mikines, Kari J

AU - van Hall, Gerrit

AU - Lindegaard, Birgitte

AU - Solomon, Thomas

AU - Pedersen, Bente K

PY - 2013/10

Y1 - 2013/10

N2 - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P

AB - Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigated whether endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and ten healthy men with normal testosterone levels underwent 12 weeks of endurance training. Primary endpoints were insulin sensitivity (euglycemic-hyperinsulinemic clamps with concomitant glucose-tracer infusion) and body composition (dual-energy X-ray absorptiometry and magnetic resonance imaging). The secondary endpoint was systemic inflammation. Statistical analysis was carried out using two-way ANOVA. Endurance training increased VO2max (ml(O2)/min per kg) by 11 and 13% in the patients and controls respectively (P

U2 - 10.1530/erc-12-0393

DO - 10.1530/erc-12-0393

M3 - Journal article

C2 - 23744766

SN - 1351-0088

VL - 20

SP - 621

EP - 632

JO - Endocrine - Related Cancer

JF - Endocrine - Related Cancer

IS - 5

ER -

Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy

Abstract

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