Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men

TY - JOUR

T1 - Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men

AU - Bladbjerg, Else Marie

AU - Skov, Jane

AU - Nordby, Pernille

AU - Stallknecht, Bente

PY - 2017

Y1 - 2017

N2 - Introduction The cardiovascular risk marker tissue plasminogen activator antigen (t-PA:Ag) can be reduced by long-term exercise interventions, but it is unknown, whether this is due to the weight loss induced by physical activity or due to the physical activity per se. Materials and methods This was tested in 60 healthy, younger (20–40 years), overweight (BMI: 25–30 kg/m2) men randomly assigned to 12 weeks of intervention in one of four groups: training (T); energy-reduced diet (D); training and increased diet (T-iD); sedentary lifestyle and unchanged diet (controls, C). Fasting blood samples were obtained before and after 12 weeks of intervention and analyzed for plasma t-PA:Ag. Results Body weight was reduced in groups T and D. We observed a decrease in t-PA:Ag from baseline to 12 weeks in all three exercise and diet intervention groups, and no change in the control group. A between-group difference in t-PA:Ag was observed at 12 weeks (p = 0.001), and this was due to lower values in T (p = 0.0005), D (p = 0.005) and T-iD (p = 0.009) compared with the control group. Total body fat mass was reduced in all three exercise groups, and we observed a positive correlation between changes in t-PA:Ag and changes in intra-abdominal and subcutaneous adipose tissue volume. Conclusions Our results demonstrate that t-PA:Ag was reduced in all three intervention groups. This suggests that 12 weeks of endurance training per se, irrespective of concomitant weight loss, beneficially affects cardiovascular risk in healthy, younger, overweight men.

AB - Introduction The cardiovascular risk marker tissue plasminogen activator antigen (t-PA:Ag) can be reduced by long-term exercise interventions, but it is unknown, whether this is due to the weight loss induced by physical activity or due to the physical activity per se. Materials and methods This was tested in 60 healthy, younger (20–40 years), overweight (BMI: 25–30 kg/m2) men randomly assigned to 12 weeks of intervention in one of four groups: training (T); energy-reduced diet (D); training and increased diet (T-iD); sedentary lifestyle and unchanged diet (controls, C). Fasting blood samples were obtained before and after 12 weeks of intervention and analyzed for plasma t-PA:Ag. Results Body weight was reduced in groups T and D. We observed a decrease in t-PA:Ag from baseline to 12 weeks in all three exercise and diet intervention groups, and no change in the control group. A between-group difference in t-PA:Ag was observed at 12 weeks (p = 0.001), and this was due to lower values in T (p = 0.0005), D (p = 0.005) and T-iD (p = 0.009) compared with the control group. Total body fat mass was reduced in all three exercise groups, and we observed a positive correlation between changes in t-PA:Ag and changes in intra-abdominal and subcutaneous adipose tissue volume. Conclusions Our results demonstrate that t-PA:Ag was reduced in all three intervention groups. This suggests that 12 weeks of endurance training per se, irrespective of concomitant weight loss, beneficially affects cardiovascular risk in healthy, younger, overweight men.

KW - Diet

KW - Endothelium

KW - Fibrinolysis

KW - Physical training

KW - Randomized

U2 - 10.1016/j.thromres.2017.02.022

DO - 10.1016/j.thromres.2017.02.022

M3 - Journal article

C2 - 28254694

AN - SCOPUS:85014023242

SN - 0049-3848

VL - 152

SP - 69

EP - 73

JO - Thrombosis Research

JF - Thrombosis Research

ER -