Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation

TY - JOUR

T1 - Endogenous thrombin potential in polycystic ovary syndrome

T2 - the association to body mass index, insulin resistance, and inflammation

AU - Aziz, Mubeena

AU - Sidelmann, Johannes J

AU - Wissing, Marie Louise Muff

AU - Faber, Jens

AU - Skouby, Sven O

PY - 2015/9/2

Y1 - 2015/9/2

N2 - OBJECTIVES: The objective of this study is to investigate plasma endogenous thrombin generation in four different phenotypes of polycystic ovary syndrome (PCOS) defined by Body Mass Index (BMI) and insulin resistance (IR). PCOS is diagnosed according to the Rotterdam criteria.DESIGN: Multicenter cross-sectional study.SETTING: Two major University Hospitals in the Capital region of Denmark.PATIENTS: Hundred forty-eight European women with PCOS were consecutively recruited during April 2010-February 2012. Clinical examination, blood sampling, and DEXA scan were performed.MAIN OUTCOME MEASURES: Endogenous thrombin potential (ETP).RESULTS: PCOS women with phenotype BMI > 25 + IR have increased potential of thrombin generation. ETP is associated with total body fat mass, IR, and CRP.CONCLUSIONS: Obese and insulin resistant women with PCOS have elevated level of ETP corresponding to increased risk of CVD. ETP is related to well-known CVD risk factors in PCOS but not in general to the Rotterdam criteria.

AB - OBJECTIVES: The objective of this study is to investigate plasma endogenous thrombin generation in four different phenotypes of polycystic ovary syndrome (PCOS) defined by Body Mass Index (BMI) and insulin resistance (IR). PCOS is diagnosed according to the Rotterdam criteria.DESIGN: Multicenter cross-sectional study.SETTING: Two major University Hospitals in the Capital region of Denmark.PATIENTS: Hundred forty-eight European women with PCOS were consecutively recruited during April 2010-February 2012. Clinical examination, blood sampling, and DEXA scan were performed.MAIN OUTCOME MEASURES: Endogenous thrombin potential (ETP).RESULTS: PCOS women with phenotype BMI > 25 + IR have increased potential of thrombin generation. ETP is associated with total body fat mass, IR, and CRP.CONCLUSIONS: Obese and insulin resistant women with PCOS have elevated level of ETP corresponding to increased risk of CVD. ETP is related to well-known CVD risk factors in PCOS but not in general to the Rotterdam criteria.

U2 - 10.3109/09513590.2015.1032930

DO - 10.3109/09513590.2015.1032930

M3 - Journal article

C2 - 26291802

SN - 0951-3590

VL - 31

SP - 720

EP - 724

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

IS - 9

ER -