Encapsulation of paclitaxel into a bio-nanocomposite. A study combining Inelastic Neutron Scattering to Thermal Analysis and Infrared Spectroscopy.

TY - GEN

T1 - Encapsulation of paclitaxel into a bio-nanocomposite. A study combining Inelastic Neutron Scattering to Thermal Analysis and Infrared Spectroscopy.

AU - Longo Martins, Murillo

AU - Nunes Bordallo, Heloisa

PY - 2015/1/23

Y1 - 2015/1/23

N2 - The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

AB - The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

U2 - 10.1051/epjconf/20158302011

DO - 10.1051/epjconf/20158302011

M3 - Conference article

SN - 2101-6275

VL - 83

JO - EPJ Web of Conferences

JF - EPJ Web of Conferences

M1 - 02011

ER -