vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates

Dereje Dadi Gudeta; Arshnee Moodley; Valeria Bortolaia; Luca Guardabassi

doi:10.1128/AAC.01880-13

vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates

Dereje Dadi Gudeta, Arshnee Moodley, Valeria Bortolaia, Luca Guardabassi

10 Citationer (Scopus)

Abstract

We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.

Originalsprog	Engelsk
Tidsskrift	Antimicrobial Agents and Chemotherapy
Vol/bind	58
Udgave nummer	3
Sider (fra-til)	1768-1770
Antal sider	3
ISSN	0066-4804
DOI	https://doi.org/10.1128/AAC.01880-13
Status	Udgivet - mar. 2014

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10.1128/AAC.01880-13

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abstract = "We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.",

author = "Gudeta, {Dereje Dadi} and Arshnee Moodley and Valeria Bortolaia and Luca Guardabassi",

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AU - Gudeta, Dereje Dadi

AU - Moodley, Arshnee

AU - Bortolaia, Valeria

AU - Guardabassi, Luca

PY - 2014/3

Y1 - 2014/3

N2 - We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.

AB - We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.

U2 - 10.1128/AAC.01880-13

DO - 10.1128/AAC.01880-13

M3 - Journal article

C2 - 24342631

SN - 0066-4804

VL - 58

SP - 1768

EP - 1770

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates

Abstract

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