In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia Solium cysts

S. Cederberg; C.S. Sikasunge; Åsa Andersson; Maria Vang Johansen

doi:10.1155/2012/363276

In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia Solium cysts

S. Cederberg, C.S. Sikasunge, Åsa Andersson, Maria Vang Johansen

5 Citationer (Scopus)

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Abstract

Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. The drug does not kill brain cysts and is not registered for use in pigs. Latest its safety in the recommended dose has been questioned. The aim of this study was to investigate two alternative anthelminthics. The efficacy of praziquantel and ivermectin was compared to oxfendazole In Vitro on Taenia solium. Cysts of T. solium were isolated from infected pork and incubated in culture media together with the drugs. The degree of evagination was used as effect measurement and determined after 6 hours. Praziquantel had a half maximal effective concentration (EC ₅₀) of value 0.006 ± 0.001 μg/mL. Ivermectin did not show any impact on the evagination in concentrations from 0.001 to 30μg/mL and neither did oxfendazole in concentrations from 0.001 to 50μg/mL.

Originalsprog	Engelsk
Tidsskrift	Journal of Parasitology Research
Vol/bind	2012
Antal sider	4
ISSN	2090-0023
DOI	https://doi.org/10.1155/2012/363276
Status	Udgivet - 2012

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10.1155/2012/363276

In Vitro Efficacy Testing of Praziquantel, Ivermectin, and Oxfendazole against Taenia Solium CystsForlagets udgivne version, 495 KB

Citationsformater

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abstract = "Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. The drug does not kill brain cysts and is not registered for use in pigs. Latest its safety in the recommended dose has been questioned. The aim of this study was to investigate two alternative anthelminthics. The efficacy of praziquantel and ivermectin was compared to oxfendazole In Vitro on Taenia solium. Cysts of T. solium were isolated from infected pork and incubated in culture media together with the drugs. The degree of evagination was used as effect measurement and determined after 6 hours. Praziquantel had a half maximal effective concentration (EC 50) of value 0.006 ± 0.001 μg/mL. Ivermectin did not show any impact on the evagination in concentrations from 0.001 to 30μg/mL and neither did oxfendazole in concentrations from 0.001 to 50μg/mL.",

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AU - Cederberg, S.

AU - Sikasunge, C.S.

AU - Andersson, Åsa

AU - Johansen, Maria Vang

N1 - Article ID 363276

PY - 2012

Y1 - 2012

N2 - Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. The drug does not kill brain cysts and is not registered for use in pigs. Latest its safety in the recommended dose has been questioned. The aim of this study was to investigate two alternative anthelminthics. The efficacy of praziquantel and ivermectin was compared to oxfendazole In Vitro on Taenia solium. Cysts of T. solium were isolated from infected pork and incubated in culture media together with the drugs. The degree of evagination was used as effect measurement and determined after 6 hours. Praziquantel had a half maximal effective concentration (EC 50) of value 0.006 ± 0.001 μg/mL. Ivermectin did not show any impact on the evagination in concentrations from 0.001 to 30μg/mL and neither did oxfendazole in concentrations from 0.001 to 50μg/mL.

AB - Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. The drug does not kill brain cysts and is not registered for use in pigs. Latest its safety in the recommended dose has been questioned. The aim of this study was to investigate two alternative anthelminthics. The efficacy of praziquantel and ivermectin was compared to oxfendazole In Vitro on Taenia solium. Cysts of T. solium were isolated from infected pork and incubated in culture media together with the drugs. The degree of evagination was used as effect measurement and determined after 6 hours. Praziquantel had a half maximal effective concentration (EC 50) of value 0.006 ± 0.001 μg/mL. Ivermectin did not show any impact on the evagination in concentrations from 0.001 to 30μg/mL and neither did oxfendazole in concentrations from 0.001 to 50μg/mL.

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In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia Solium cysts

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