Elevated transferrin saturation and risk of diabetes: Three population-based studies

TY - JOUR

T1 - Elevated transferrin saturation and risk of diabetes

T2 - Three population-based studies

AU - Ellervik, Christina

AU - Mandrup-Poulsen, Thomas

AU - Andersen, Henrik Ullits

AU - Tybjærg-Hansen, Anne

AU - Frandsen, Merete

AU - Birgens, Henrik

AU - Nordestgaard, Børge G

PY - 2011/10

Y1 - 2011/10

N2 - OBJECTIVE We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form of diabetes, as well as type 1 or type 2 diabetes separately. RESEARCH DESIGN AND METHODS We used two general population studies, The Copenhagen City Heart Study (CCHS, N = 9,121) and The Copenhagen General Population Study (CGPS, N = 24,195), as well as a 1:1 age- and sex-matched population-based case-control study with 6,129 patients with diabetes from the Steno Diabetes Centre and 6,129 control subjects, totaling 8,535 patients with diabetes and 37,039 control subjects. RESULTS In the combined studies, odds ratios in those with transferrin saturation =50% vs.

AB - OBJECTIVE We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form of diabetes, as well as type 1 or type 2 diabetes separately. RESEARCH DESIGN AND METHODS We used two general population studies, The Copenhagen City Heart Study (CCHS, N = 9,121) and The Copenhagen General Population Study (CGPS, N = 24,195), as well as a 1:1 age- and sex-matched population-based case-control study with 6,129 patients with diabetes from the Steno Diabetes Centre and 6,129 control subjects, totaling 8,535 patients with diabetes and 37,039 control subjects. RESULTS In the combined studies, odds ratios in those with transferrin saturation =50% vs.

U2 - 10.2337/dc11-0416

DO - 10.2337/dc11-0416

M3 - Journal article

C2 - 21873562

SN - 0149-5992

VL - 34

SP - 2256

EP - 2258

JO - Diabetes Care

JF - Diabetes Care

IS - 10

ER -