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EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
Michael V Grandal, Roza Zandi, Mikkel W Pedersen,
Berthe M Willumsen
, Bo van Deurs, Hans S Poulsen
Morphogenesis and Differentiation Program
Cellebiologi og Fysiologi
Institut for Cellulær og Molekylær Medicin
94
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Keyphrases
Lysosome
100%
EGFRvIII
100%
C-Cbl
18%
Mutant Variants
9%
Long Lifetime
9%
Cell Systems
9%
Epidermal Growth Factor Receptor Family
9%
Receptor Downregulation
9%
Internalization Efficiency
9%
Tyrosine Residue
9%
Endogenous Levels
9%
Ubiquitinylation
9%
Tyrosine Phosphorylation
9%
Grb2
9%
Neuroscience
Lysosome
100%
Internalization
100%
Ubiquitin Protein Ligase
16%
Pharmacology, Toxicology and Pharmaceutical Science
Epidermal Growth Factor Receptor
100%
Receptor
66%
Ubiquitin Protein Ligase
16%
Malignant Neoplasm
16%
Biochemistry, Genetics and Molecular Biology
Lysosome
100%
Receptor down Regulation
16%
Lifespan
16%
Protein Catabolism
16%