TY - JOUR
T1 - Efficacy of a liquid low-energy formula diet in achieving preoperative target weight loss before bariatric surgery
AU - Nielsen, Lone Vestergaard
AU - Nielsen, Mette Søndergaard
AU - Schmidt, Julie Berg
AU - Pedersen, Sue D
AU - Sjödin, Anders Mikael
N1 - CURIS 2016 NEXS 145
PY - 2016/5/30
Y1 - 2016/5/30
N2 - A preoperative weight loss of 8 % is a prerequisite to undergo bariatric surgery (BS) in Denmark. The aim of the present study was to evaluate the efficacy of a 7- or an 11-week low-energy diet (LCD) for achieving preoperative target weight before BS. A total of thirty obese patients (BMI 46·0 (SD 4·4) kg/m2) followed an LCD (Cambridge Weight Plan®, 4184 kJ/d (1000 kcal/d)) for 7 or 11 weeks as preparation for BS. Anthropometric measurements including body composition (dual-energy X-ray absorptiometry), blood parameters and blood pressure were assessed at weeks 0, 7 and 11. At week 7, the majority of patients (77 %) had reached their target weight, and this was achieved after 5·4 (SEM 0·3) weeks. Mean weight loss was 9·3 (SEM 0·5) % (P < 0·01) and consisted of 41·6 % fat-free mass (FFM) and 58·4 % fat mass. The weight loss was accompanied by a decrease in systolic and diastolic blood pressure (7·1 (SEM 2·3) and 7·3 (SEM 1·8) mmHg, respectively, all P < 0·01) as well as an improved metabolic profile (8·2 (SEM 1·8) % decrease in fasting glucose (P < 0·01), 28·6 (SEM 6·4) % decrease in fasting insulin (P < 0·01), 23·1 (SEM 2·2) % decrease in LDL (P < 0·01), and 9·7 (SEM 4·7) % decrease in TAG (P < 0·05)). Weight, FFM and fat mass continued to decrease from week 7 to 11 (all P < 0·01), whereas no additional improvements was observed in the metabolic parameters. Severely obese patients can safely achieve preoperative target weight on an LCD within 7 weeks as part of preparation for BS. However, the considerable reduction in FFM in severely obese subjects needs further investigation.
AB - A preoperative weight loss of 8 % is a prerequisite to undergo bariatric surgery (BS) in Denmark. The aim of the present study was to evaluate the efficacy of a 7- or an 11-week low-energy diet (LCD) for achieving preoperative target weight before BS. A total of thirty obese patients (BMI 46·0 (SD 4·4) kg/m2) followed an LCD (Cambridge Weight Plan®, 4184 kJ/d (1000 kcal/d)) for 7 or 11 weeks as preparation for BS. Anthropometric measurements including body composition (dual-energy X-ray absorptiometry), blood parameters and blood pressure were assessed at weeks 0, 7 and 11. At week 7, the majority of patients (77 %) had reached their target weight, and this was achieved after 5·4 (SEM 0·3) weeks. Mean weight loss was 9·3 (SEM 0·5) % (P < 0·01) and consisted of 41·6 % fat-free mass (FFM) and 58·4 % fat mass. The weight loss was accompanied by a decrease in systolic and diastolic blood pressure (7·1 (SEM 2·3) and 7·3 (SEM 1·8) mmHg, respectively, all P < 0·01) as well as an improved metabolic profile (8·2 (SEM 1·8) % decrease in fasting glucose (P < 0·01), 28·6 (SEM 6·4) % decrease in fasting insulin (P < 0·01), 23·1 (SEM 2·2) % decrease in LDL (P < 0·01), and 9·7 (SEM 4·7) % decrease in TAG (P < 0·05)). Weight, FFM and fat mass continued to decrease from week 7 to 11 (all P < 0·01), whereas no additional improvements was observed in the metabolic parameters. Severely obese patients can safely achieve preoperative target weight on an LCD within 7 weeks as part of preparation for BS. However, the considerable reduction in FFM in severely obese subjects needs further investigation.
U2 - 10.1017/jns.2016.13
DO - 10.1017/jns.2016.13
M3 - Journal article
C2 - 27293559
SN - 2048-6790
VL - 5
JO - Journal of Nutritional Science
JF - Journal of Nutritional Science
M1 - e22
ER -