Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial

George PrayGod; Andrea M Rehman; Jonathan C. K. Wells; Molly Chisenga; Joshua Siame; Kidola Jeremiah; Lackson Kasonka; Susannah Woodd; John Changalucha; Paul Kelly; John R Koethe; Douglas C Heimburger; Henrik Friis; Suzanne Filteau

doi:10.1017/jns.2019.15

Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial

George PrayGod^*, Andrea M Rehman, Jonathan C. K. Wells, Molly Chisenga, Joshua Siame, Kidola Jeremiah, Lackson Kasonka, Susannah Woodd, John Changalucha, Paul Kelly, John R Koethe, Douglas C Heimburger, Henrik Friis, Suzanne Filteau

^*Corresponding author af dette arbejde

Ernæring og Sundhed hos børn og voksne

1 Citationer (Scopus)

18 Downloads (Pure)

Abstract

Lipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m ² were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium ( ² H) diluted water (D ₂ O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D ₂ O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D ₂ O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI -0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D ₂ O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients.

Originalsprog	Engelsk
Artikelnummer	e19
Tidsskrift	Journal of Nutritional Science
Vol/bind	8
Antal sider	12
ISSN	2048-6790
DOI	https://doi.org/10.1017/jns.2019.15
Status	Udgivet - 2019

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1017/jns.2019.15Licens: CC BY-NC-ND

PrayGod et al_Journal of Nutritional Science_2019_Vol 8_e19Forlagets udgivne version, 1,05 MBLicens: CC BY-NC-ND

Citationsformater

PrayGod, G., Rehman, A. M., Wells, J. C. K., Chisenga, M., Siame, J., Jeremiah, K., Kasonka, L., Woodd, S., Changalucha, J., Kelly, P., Koethe, J. R., Heimburger, D. C., Friis, H., & Filteau, S. (2019). Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial. Journal of Nutritional Science, 8, [e19]. https://doi.org/10.1017/jns.2019.15

Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy : A randomised controlled trial. / PrayGod, George; Rehman, Andrea M; Wells, Jonathan C. K. et al.

I: Journal of Nutritional Science, Bind 8, e19, 2019.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

PrayGod, G, Rehman, AM, Wells, JCK, Chisenga, M, Siame, J, Jeremiah, K, Kasonka, L, Woodd, S, Changalucha, J, Kelly, P, Koethe, JR, Heimburger, DC, Friis, H & Filteau, S 2019, 'Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial', Journal of Nutritional Science, bind 8, e19. https://doi.org/10.1017/jns.2019.15

@article{7277b5ee8c53487cb5c786f7329ab2ca,

title = "Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial",

abstract = " Lipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m 2 were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium ( 2 H) diluted water (D 2 O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D 2 O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D 2 O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI -0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D 2 O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients. ",

keywords = "Antiretroviral therapy, Body composition, Handgrip strength, Malnutrition, Minerals, Vitamins",

author = "George PrayGod and Rehman, {Andrea M} and Wells, {Jonathan C. K.} and Molly Chisenga and Joshua Siame and Kidola Jeremiah and Lackson Kasonka and Susannah Woodd and John Changalucha and Paul Kelly and Koethe, {John R} and Heimburger, {Douglas C} and Henrik Friis and Suzanne Filteau",

note = "CURIS 2019 NEXS 181",

year = "2019",

doi = "10.1017/jns.2019.15",

language = "English",

volume = "8",

journal = "Journal of Nutritional Science",

issn = "2048-6790",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy

T2 - A randomised controlled trial

AU - PrayGod, George

AU - Rehman, Andrea M

AU - Wells, Jonathan C. K.

AU - Chisenga, Molly

AU - Siame, Joshua

AU - Jeremiah, Kidola

AU - Kasonka, Lackson

AU - Woodd, Susannah

AU - Changalucha, John

AU - Kelly, Paul

AU - Koethe, John R

AU - Heimburger, Douglas C

AU - Friis, Henrik

AU - Filteau, Suzanne

N1 - CURIS 2019 NEXS 181

PY - 2019

Y1 - 2019

N2 - Lipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m 2 were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium ( 2 H) diluted water (D 2 O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D 2 O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D 2 O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI -0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D 2 O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients.

AB - Lipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m 2 were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium ( 2 H) diluted water (D 2 O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D 2 O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D 2 O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI -0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D 2 O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients.

KW - Antiretroviral therapy

KW - Body composition

KW - Handgrip strength

KW - Malnutrition

KW - Minerals

KW - Vitamins

U2 - 10.1017/jns.2019.15

DO - 10.1017/jns.2019.15

M3 - Journal article

C2 - 31143445

AN - SCOPUS:85065853464

SN - 2048-6790

VL - 8

JO - Journal of Nutritional Science

JF - Journal of Nutritional Science

M1 - e19

ER -

Effects on body composition and handgrip strength of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: A randomised controlled trial

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater