TY - JOUR
T1 - Effects of tilting on central hemodynamics and homeostatic mechanisms in cirrhosis
AU - Møller, Søren
AU - Nørgaard, Annette
AU - Henriksen, Jens H
AU - Frandsen, Erik
AU - Bendtsen, Flemming
N1 - Keywords: Adult; Atrial Natriuretic Factor; Blood Pressure; Calcitonin Gene-Related Peptide; Compliance; Female; Head-Down Tilt; Heart Rate; Hemodynamics; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Norepinephrine; Plasma Volume; Posture; Renin; Vascular Resistance
PY - 2004
Y1 - 2004
N2 - Patients with cirrhosis have a hyperdynamic circulation and an abnormal blood volume distribution with central hypovolemia, an activated sympathetic nervous system (SNS) as well as the renin-angiotensin-aldosterone system (RAAS). As the hyperdynamic circulation in cirrhosis may be present only in the supine patient, we studied the humoral and central hemodynamic responses to changes with posture. Twenty-three patients with alcoholic cirrhosis (Child-Turcotte-Pugh classes A/B/C: 2/13/8) and 14 healthy controls were entered. Measurements of central hemodynamics and activation of SNS and RAAS were taken in the supine position, after 30 degrees head-down tilting, and after 60 degrees passive head-up tilting for a maximum of 20 minutes. After the head-up tilting, the central blood volume (CBV) decreased in both groups, but the decrease was significantly smaller in patients than in controls (-19% vs. -36%, P <.01). Central circulation time increased only in the patients (+30% vs. -1%, P <.01). The absolute increases in circulating norepinephrine and renin after head-up tilting were significantly higher in the patients than in the controls (P <.05 and P <.01, respectively). In patients with cirrhosis, changes in SNS and RAAS were related to changes in arterial blood pressure, systemic vascular resistance, heart rate, non-CBV, plasma volume, and arterial compliance. In conclusion, cardiovascular and humoral responses to changes in posture are clearly abnormal in patients with cirrhosis. Head-up tilting decreases the CBV less in patients with cirrhosis, and the results suggest a differential regulation of central hemodynamics in patients with cirrhosis.
AB - Patients with cirrhosis have a hyperdynamic circulation and an abnormal blood volume distribution with central hypovolemia, an activated sympathetic nervous system (SNS) as well as the renin-angiotensin-aldosterone system (RAAS). As the hyperdynamic circulation in cirrhosis may be present only in the supine patient, we studied the humoral and central hemodynamic responses to changes with posture. Twenty-three patients with alcoholic cirrhosis (Child-Turcotte-Pugh classes A/B/C: 2/13/8) and 14 healthy controls were entered. Measurements of central hemodynamics and activation of SNS and RAAS were taken in the supine position, after 30 degrees head-down tilting, and after 60 degrees passive head-up tilting for a maximum of 20 minutes. After the head-up tilting, the central blood volume (CBV) decreased in both groups, but the decrease was significantly smaller in patients than in controls (-19% vs. -36%, P <.01). Central circulation time increased only in the patients (+30% vs. -1%, P <.01). The absolute increases in circulating norepinephrine and renin after head-up tilting were significantly higher in the patients than in the controls (P <.05 and P <.01, respectively). In patients with cirrhosis, changes in SNS and RAAS were related to changes in arterial blood pressure, systemic vascular resistance, heart rate, non-CBV, plasma volume, and arterial compliance. In conclusion, cardiovascular and humoral responses to changes in posture are clearly abnormal in patients with cirrhosis. Head-up tilting decreases the CBV less in patients with cirrhosis, and the results suggest a differential regulation of central hemodynamics in patients with cirrhosis.
U2 - 10.1002/hep.20416
DO - 10.1002/hep.20416
M3 - Journal article
C2 - 15382169
SN - 0270-9139
VL - 40
SP - 811
EP - 819
JO - Hepatology
JF - Hepatology
IS - 4
ER -