Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects

Michael Højby Rasmussen; Anders Juul; Lise Lund Kjems; Jannik Hilsted

doi:http://dx.doi.org/10.1530/eje.1.02246

Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects

Michael Højby Rasmussen, Anders Juul, Lise Lund Kjems, Jannik Hilsted

28 Citationer (Scopus)

Abstract

Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD).

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	155
Udgave nummer	4
Sider (fra-til)	575-81
Antal sider	7
ISSN	0804-4643
DOI	https://doi.org/10.1530/eje.1.02246
Status	Udgivet - 2006

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

http://dx.doi.org/10.1530/eje.1.02246

Citationsformater

Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects. / Rasmussen, Michael Højby; Juul, Anders; Kjems, Lise Lund et al.

I: European Journal of Endocrinology, Bind 155, Nr. 4, 2006, s. 575-81.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{9f19280893454ff9a1ad1eb3d56432c5,

title = "Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects",

abstract = "Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD).",

author = "Rasmussen, {Michael H{\o}jby} and Anders Juul and Kjems, {Lise Lund} and Jannik Hilsted",

year = "2006",

doi = "http://dx.doi.org/10.1530/eje.1.02246",

language = "English",

volume = "155",

pages = "575--81",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "4",

}

TY - JOUR

T1 - Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects

AU - Rasmussen, Michael Højby

AU - Juul, Anders

AU - Kjems, Lise Lund

AU - Hilsted, Jannik

PY - 2006

Y1 - 2006

N2 - Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD).

AB - Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD).

U2 - http://dx.doi.org/10.1530/eje.1.02246

DO - http://dx.doi.org/10.1530/eje.1.02246

M3 - Journal article

SN - 0804-4643

VL - 155

SP - 575

EP - 581

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 4

ER -

Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater