Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals

TY - JOUR

T1 - Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals

AU - Major-Pedersen, A

AU - Ihlemann, N

AU - Hermann, T S

AU - Christiansen, B

AU - Dominguez, H

AU - Kveiborg, B.

AU - Nielsen, D B

AU - Svendsen, O L

AU - Køber, L

AU - Torp-Pedersen, C

N1 - Keywords: Blood Glucose; Blood Pressure; Electrocardiography; Endothelium, Vascular; Glucose; Glucose Tolerance Test; Humans; Insulin; Kinetics; Placebos; Reference Values

PY - 2008

Y1 - 2008

N2 - BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. METHODS: We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. RESULTS: The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. CONCLUSION: Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.

AB - BACKGROUND/AIMS: Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. METHODS: We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. RESULTS: The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: 4.80 +/- 1.41 (P = .009) and 2.34 +/- 1.47 (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. CONCLUSION: Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.

U2 - 10.1155/2008/672021

DO - 10.1155/2008/672021

M3 - Journal article

C2 - 18350125

SN - 1687-5214

VL - 2008

SP - 672021

JO - Experimental Diabetes Research

JF - Experimental Diabetes Research

ER -