Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats: studies of lymphoid and non--lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer

H P Hougen; B Klausen

Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats: studies of lymphoid and non--lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer

H P Hougen, B Klausen

Afdeling for Retspatologi

7 Citationer (Scopus)

Abstract

Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.

Originalsprog	Engelsk
Tidsskrift	Laboratory Animals
Vol/bind	18
Udgave nummer	1
Sider (fra-til)	7-14
Antal sider	8
ISSN	0023-6772
Status	Udgivet - jan. 1984

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Citationsformater

Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats : studies of lymphoid and non--lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer. / Hougen, H P; Klausen, B.

I: Laboratory Animals, Bind 18, Nr. 1, 01.1984, s. 7-14.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats: studies of lymphoid and non--lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer",

abstract = "Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.",

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author = "Hougen, {H P} and B Klausen",

year = "1984",

month = jan,

language = "English",

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journal = "Laboratory Animals",

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T1 - Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats

T2 - studies of lymphoid and non--lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer

AU - Hougen, H P

AU - Klausen, B

PY - 1984/1

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N2 - Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.

AB - Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.

KW - Age Factors

KW - Animals

KW - Bone Marrow Cells

KW - Female

KW - Heterozygote

KW - Homozygote

KW - Leukocyte Count

KW - Lymphoid Tissue

KW - Male

KW - Organ Size

KW - Rats

KW - Rats, Inbred Lew

KW - Rats, Nude

M3 - Journal article

C2 - 10628778

SN - 0023-6772

VL - 18

SP - 7

EP - 14

JO - Laboratory Animals

JF - Laboratory Animals

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ER -