TY - JOUR
T1 - Effects of glutamine on the immune system
T2 - Influence of muscular exercise and HIV infection
AU - Rohde, T.
AU - Ullum, H.
AU - Palmo Rasmussen, J.
AU - Kristensen, J. H.
AU - Newsholme, E.
AU - Pedersen, B. K.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Glutamine increased the proliferative response and the lymphokine- activated killer cell activity of blood mononuclear cells isolated from normal healthy subjects (n = 6) in a dose-dependent manner, with optimum at 0.3-1.0 mM. The relative fraction of CD3+, CD4+, CD8+, CD14+, CD16+, and CD19+ cells was not changed by glutamine at a concentration of 0.6 mM, except in the phytohemagglutinin-stimulated proliferation experiment where the fraction of CD4+, and therefore CD3+ cells, increased. The natural killer cell activity was not influenced by glutamine. Human immunodeficiency virus (HIV)-seropositive subjects (n = 8) who performed concentric bicycle exercise for 1 h at 75% of maximal O2 consumption had an overall lower phytohemagglutinin-stimulated proliferative response, compared with the HIV- seronegative control group (n = 7). The proliferation during exercise was lower in both the HIV-seropositive and the HIV-seronegative group. Addition of glutamine in vitro did not normalize the lower proliferation in the HIV- seropositive group or the attenuated proliferation seen during exercise in both groups.
AB - Glutamine increased the proliferative response and the lymphokine- activated killer cell activity of blood mononuclear cells isolated from normal healthy subjects (n = 6) in a dose-dependent manner, with optimum at 0.3-1.0 mM. The relative fraction of CD3+, CD4+, CD8+, CD14+, CD16+, and CD19+ cells was not changed by glutamine at a concentration of 0.6 mM, except in the phytohemagglutinin-stimulated proliferation experiment where the fraction of CD4+, and therefore CD3+ cells, increased. The natural killer cell activity was not influenced by glutamine. Human immunodeficiency virus (HIV)-seropositive subjects (n = 8) who performed concentric bicycle exercise for 1 h at 75% of maximal O2 consumption had an overall lower phytohemagglutinin-stimulated proliferative response, compared with the HIV- seronegative control group (n = 7). The proliferation during exercise was lower in both the HIV-seropositive and the HIV-seronegative group. Addition of glutamine in vitro did not normalize the lower proliferation in the HIV- seropositive group or the attenuated proliferation seen during exercise in both groups.
KW - exercise
KW - glutamine
KW - human immunodeficiency virus
KW - immune system
KW - lymphocyte subpopulations
KW - lymphocyte-proliferative response
KW - lymphokine- activated killer cells
KW - natural killer cells
UR - http://www.scopus.com/inward/record.url?scp=0029102045&partnerID=8YFLogxK
U2 - 10.1152/jappl.1995.79.1.146
DO - 10.1152/jappl.1995.79.1.146
M3 - Journal article
C2 - 7559212
AN - SCOPUS:0029102045
SN - 8750-7587
VL - 79
SP - 146
EP - 150
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 1
ER -
