@article{73969d50a0dd11dd86a6000ea68e967b,
title = "Effects of chloroquine, mefloquine and quinine on natural killer cell activity in vitro. An analysis of the inhibitory mechanism",
abstract = "Natural killer (NK) cell activity against K 562 target cells was inhibited by pharmacological concentrations of chloroquine, mefloquine and quinine. The most potent were mefloquine and quinine. The drug-induced inhibition of the NK cell activity was abolished by addition of alpha-interferon (IF) or interleukin 2 (Il-2); preincubation of mononuclear cells with IF or Il-2 followed by addition of anti-malarial drugs decreased the inhibitory effects of the drugs. The drug-induced inhibition of the NK cell activity was not dependent on the presence of monocytes. Using monocyte depleted Percoll fractionated NK cell enriched populations in a single cell agarose assay, it was shown that the inhibitory effects of mefloquine, but not of chloroquine and quinine were due to an inhibition of the formation of effector/target cell conjugates.",
author = "Pedersen, {B K} and Bygbjerg, {I C} and Theander, {T G} and Andersen, {B J}",
note = "Keywords: Cell Adhesion; Chloroquine; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunity, Natural; Interferons; Interleukin-2; Killer Cells, Natural; Mefloquine; Quinine; Quinolines",
year = "1986",
language = "English",
volume = "41",
pages = "537--42",
journal = "Allergy. European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "7",
}