Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain.

TY - JOUR

T1 - Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain.

AU - Wong, D F

AU - Wagner, H N

AU - Dannals, R F

AU - Links, J M

AU - Frost, J J

AU - Ravert, H T

AU - Wilson, A A

AU - Rosenbaum, A E

AU - Gjedde, A

AU - Douglass, K H

PY - 1984

Y1 - 1984

N2 - D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females.

AB - D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females.

M3 - Journal article

C2 - 6334363

SN - 0036-8075

VL - 226

SP - 1393

EP - 1396

JO - Science

JF - Science

IS - 4681

ER -