TY - JOUR
T1 - Effects of activity-dependent strategies on regeneration and plasticity after peripheral nerve injuries
AU - Udina, Esther
AU - Cobianchi, Stefano
AU - Allodi, Ilary
AU - Navarro, Xavier
N1 - Copyright © 2011 Elsevier GmbH. All rights reserved.
PY - 2011/7
Y1 - 2011/7
N2 - Peripheral nerve injuries result in loss of motor, sensory and autonomic functions of the denervated limb, but are also accompanied by positive symptoms, such as hyperreflexia, hyperalgesia and pain. Strategies to improve functional recovery after neural injuries have to address the enhancement of axonal regeneration and target reinnervation and also the modulation of the abnormal plasticity of neuronal circuits. By enhancing sensory inputs and/or motor outputs, activity-dependent therapies, like electrostimulation or exercise, have been shown to positively influence neuromuscular functional recovery and to modulate the plastic central changes after experimental nerve injuries. However, it is important to take into account that the type of treatment, the intensity and duration of the protocol, and the period during which it is applied after the injury are factors that determine beneficial or detrimental effects on functional recovery. The adequate maintenance of activity of neural circuits and denervated muscles results in increased trophic factor release to act on regenerating axons and on central plastic changes. Among the different neurotrophins, BDNF seems a key player in the beneficial effects of activity-dependent therapies after nerve injuries.
AB - Peripheral nerve injuries result in loss of motor, sensory and autonomic functions of the denervated limb, but are also accompanied by positive symptoms, such as hyperreflexia, hyperalgesia and pain. Strategies to improve functional recovery after neural injuries have to address the enhancement of axonal regeneration and target reinnervation and also the modulation of the abnormal plasticity of neuronal circuits. By enhancing sensory inputs and/or motor outputs, activity-dependent therapies, like electrostimulation or exercise, have been shown to positively influence neuromuscular functional recovery and to modulate the plastic central changes after experimental nerve injuries. However, it is important to take into account that the type of treatment, the intensity and duration of the protocol, and the period during which it is applied after the injury are factors that determine beneficial or detrimental effects on functional recovery. The adequate maintenance of activity of neural circuits and denervated muscles results in increased trophic factor release to act on regenerating axons and on central plastic changes. Among the different neurotrophins, BDNF seems a key player in the beneficial effects of activity-dependent therapies after nerve injuries.
KW - Animals
KW - Models, Animal
KW - Motor Activity/physiology
KW - Nerve Regeneration/physiology
KW - Neuralgia/physiopathology
KW - Neuronal Plasticity/physiology
KW - Peripheral Nerve Injuries
KW - Peripheral Nerves/physiology
KW - Physical Conditioning, Animal/physiology
KW - Rats
U2 - 10.1016/j.aanat.2011.02.012
DO - 10.1016/j.aanat.2011.02.012
M3 - Review
C2 - 21514121
SN - 0940-9602
VL - 193
SP - 347
EP - 353
JO - Annals of Anatomy
JF - Annals of Anatomy
IS - 4
ER -