Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

Lea Tischmann; Mathijs Drummen; Blandine Gatta-Cherifi; Anne Raben; Mikael Fogelholm; Bolette Hartmann; Jens Juul Holst; Isabelle Matias; Daniela Cota; Ronald P Mensink; Joris Peters; Margriet S Westerterp-Plantenga; Tanja C Adam

doi:10.3390/nu11102269

Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

Lea Tischmann, Mathijs Drummen, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Bolette Hartmann, Jens Juul Holst, Isabelle Matias, Daniela Cota, Ronald P Mensink, Joris Peters, Margriet S Westerterp-Plantenga, Tanja C Adam

10 Citationer (Scopus)

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Abstract

Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 ± 5.9 years; body mass index (BMI) 28.9 ± 3.9 kg/m²) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.

Originalsprog	Engelsk
Artikelnummer	2269
Tidsskrift	Nutrients
Vol/bind	11
Antal sider	16
ISSN	2072-6643
DOI	https://doi.org/10.3390/nu11102269
Status	Udgivet - 2019

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10.3390/nu11102269Licens: CC BY

Tischmann et al_Nutrients_2019_Vol 11_e2269Forlagets udgivne version, 2,41 MBLicens: CC BY

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Tischmann, L., Drummen, M., Gatta-Cherifi, B., Raben, A., Fogelholm, M., Hartmann, B., Holst, J. J., Matias, I., Cota, D., Mensink, R. P., Peters, J., Westerterp-Plantenga, M. S., & Adam, T. C. (2019). Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study. Nutrients, 11, [2269]. https://doi.org/10.3390/nu11102269

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title = "Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study",

abstract = "Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 ± 5.9 years; body mass index (BMI) 28.9 ± 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.",

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author = "Lea Tischmann and Mathijs Drummen and Blandine Gatta-Cherifi and Anne Raben and Mikael Fogelholm and Bolette Hartmann and Holst, {Jens Juul} and Isabelle Matias and Daniela Cota and Mensink, {Ronald P} and Joris Peters and Westerterp-Plantenga, {Margriet S} and Adam, {Tanja C}",

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TY - JOUR

T1 - Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

AU - Tischmann, Lea

AU - Drummen, Mathijs

AU - Gatta-Cherifi, Blandine

AU - Raben, Anne

AU - Fogelholm, Mikael

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Matias, Isabelle

AU - Cota, Daniela

AU - Mensink, Ronald P

AU - Peters, Joris

AU - Westerterp-Plantenga, Margriet S

AU - Adam, Tanja C

N1 - CURIS 2019 NEXS 305

PY - 2019

Y1 - 2019

N2 - Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 ± 5.9 years; body mass index (BMI) 28.9 ± 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.

AB - Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 ± 5.9 years; body mass index (BMI) 28.9 ± 3.9 kg/m2) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.

KW - Faculty of Science

KW - Protein

KW - Endocannabinoids

KW - Hunger

KW - Satiety

KW - Gut peptides

KW - Weight maintenance

KW - Obesity

U2 - 10.3390/nu11102269

DO - 10.3390/nu11102269

M3 - Journal article

C2 - 31546629

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

M1 - 2269

ER -

Effects of a high-protein/moderate-carbohydrate diet on appetite, gut peptides, and endocannabinoids — A Preview study

Abstract

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