Effect of trefoil factors on the viscoelastic properties of mucus gels

L Thim; F Madsen; S S Poulsen; Steen Seier Poulsen

Effect of trefoil factors on the viscoelastic properties of mucus gels

L Thim, F Madsen, S S Poulsen, Steen Seier Poulsen

Endocrinology and Metabolism

185 Citationer (Scopus)

Abstract

Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Investigation
Vol/bind	32
Udgave nummer	7
Sider (fra-til)	519-27
Antal sider	9
ISSN	0014-2972
Status	Udgivet - 1 jul. 2002

Citationsformater

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title = "Effect of trefoil factors on the viscoelastic properties of mucus gels",

abstract = "Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.",

keywords = "Animals, Cattle, Elasticity, Gels, Growth Substances, Humans, Immunohistochemistry, Mucins, Muscle Proteins, Neuropeptides, Peptides, Proteins, Rheology, Sputum, Swine, Tumor Suppressor Proteins, Viscosity",

author = "L Thim and F Madsen and Poulsen, {S S} and Poulsen, {Steen Seier}",

year = "2002",

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language = "English",

volume = "32",

pages = "519--27",

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TY - JOUR

T1 - Effect of trefoil factors on the viscoelastic properties of mucus gels

AU - Thim, L

AU - Madsen, F

AU - Poulsen, S S

AU - Poulsen, Steen Seier

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.

AB - Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.

KW - Animals

KW - Cattle

KW - Elasticity

KW - Gels

KW - Growth Substances

KW - Humans

KW - Immunohistochemistry

KW - Mucins

KW - Muscle Proteins

KW - Neuropeptides

KW - Peptides

KW - Proteins

KW - Rheology

KW - Sputum

KW - Swine

KW - Tumor Suppressor Proteins

KW - Viscosity

M3 - Journal article

C2 - 12153553

SN - 0014-2972

VL - 32

SP - 519

EP - 527

JO - Zeitschrift fur klinische Medizin

JF - Zeitschrift fur klinische Medizin

IS - 7

ER -

Effect of trefoil factors on the viscoelastic properties of mucus gels

Abstract

Fingeraftryk

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