Effect of new manganese contrast agent on tissue intensities in human volunteers: Comparison of 0.23, 0.6 and 1.5T MRI, a part of a phase I trail

TY - JOUR

T1 - Effect of new manganese contrast agent on tissue intensities in human volunteers

T2 - Comparison of 0.23, 0.6 and 1.5T MRI, a part of a phase I trail

AU - Chabanova, E.

AU - Thomsen, H. S.

AU - Løgager, V.

AU - Moller, J. M.

AU - Brage, K.

AU - Fogh, K.

AU - Bovin, J.

AU - Elmig, J.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - To evaluate the effect of a new oral manganese contrast agent (CMC-001) on magnetic resonance imaging (MRI) intensities at different magnetic field strengths. Twelve healthy volunteers underwent abdominal MRI 1 week before and within 2.5-4.5 h after CMC-001 (MnCl2 and absorption promoters dissolved in water) intake at three different MR scanners of 0.23, 0.6 and 1.5 T. Image contrast and intensity enhancement of liver and pancreas were analysed relatively to muscle and fat intensities. Manganese blood levels were allowed for 24 h. Whole-blood Manganese concentration levels stayed within the normal range. The liver intensities on T2w images decreased about 10% for the 1/2 contrast dose and about 20% for the full contrast dose independent of the field strength. The liver intensities on T1w images increased more than 30% for 1/2 contrast dose and over 40% for full contrast dose. The maximum T1 enhancement was achieved at the highest field. Pancreas intensities were not affected. Contrast between liver, muscle and fat intensities increased with magnetic field, as well as standard errors of the volunteer-averaged intensities. Oral intake of CMC-001 influences liver intensities and does not affect pancreas intensities at different magnetic field strengths.

AB - To evaluate the effect of a new oral manganese contrast agent (CMC-001) on magnetic resonance imaging (MRI) intensities at different magnetic field strengths. Twelve healthy volunteers underwent abdominal MRI 1 week before and within 2.5-4.5 h after CMC-001 (MnCl2 and absorption promoters dissolved in water) intake at three different MR scanners of 0.23, 0.6 and 1.5 T. Image contrast and intensity enhancement of liver and pancreas were analysed relatively to muscle and fat intensities. Manganese blood levels were allowed for 24 h. Whole-blood Manganese concentration levels stayed within the normal range. The liver intensities on T2w images decreased about 10% for the 1/2 contrast dose and about 20% for the full contrast dose independent of the field strength. The liver intensities on T1w images increased more than 30% for 1/2 contrast dose and over 40% for full contrast dose. The maximum T1 enhancement was achieved at the highest field. Pancreas intensities were not affected. Contrast between liver, muscle and fat intensities increased with magnetic field, as well as standard errors of the volunteer-averaged intensities. Oral intake of CMC-001 influences liver intensities and does not affect pancreas intensities at different magnetic field strengths.

KW - Contrast agent

KW - Liver

KW - Manganese

KW - MRI

KW - Oral intake

UR - http://www.scopus.com/inward/record.url?scp=6344291761&partnerID=8YFLogxK

U2 - 10.1007/s10334-004-0042-z

DO - 10.1007/s10334-004-0042-z

M3 - Journal article

C2 - 15258827

AN - SCOPUS:6344291761

SN - 0968-5243

VL - 17

SP - 28

EP - 35

JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

IS - 1

ER -