TY - JOUR
T1 - Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate
AU - Yafasova, Adelina
AU - Mandrup, Camilla Maria
AU - Egelund, Jon
AU - Nyberg, Michael Permin
AU - Stallknecht, Bente
AU - Hellsten, Ylva
AU - Nielsen, Lars Bo
AU - Christoffersen, Christina
N1 - CURIS 2019 NEXS 044
PY - 2019/1
Y1 - 2019/1
N2 - The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis. Healthy, late premenopausal [n 38, age 49.2 (SD 2)] and recent postmenopausal [n 37, age 53.3 (SD 3)] women from the Copenhagen Women Study participated in a 3-mo, aerobic high-intensity exercise intervention. Before training, plasma apoM was higher in postmenopausal [1.08 mol/l (SD 0.2)] compared with premenopausal [0.82 mol/l (SD 0.2)] women (P 0.0001). Plasma S1P was similar in the two groups [0.44 mol/l (SD 0.1) and 0.46 mol/l (SD 0.1), respectively]. Thus, the pretraining S1P/apoM ratio was 26% lower in postmenopausal than premenopausal women (P 0.0001). After the training program, plasma apoM increased from 0.82 mol/l (SD 0.2) to 0.90 mol/l (SD 0.3) in premenopausal women and from 1.08 mol/l (SD 0.2) to 1.16 mol/l (SD 0.3) in postmenopausal women (P 0.05). Plasma S1P increased from 0.44 mol/l (SD 0.1) to 0.47 mol/l (SD 0.1) in premenopausal women and from 0.46 mol/l (SD 0.1) to 0.48 mol/l (SD 0.1) in postmenopausal women (P 0.05). The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status.
AB - The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis. Healthy, late premenopausal [n 38, age 49.2 (SD 2)] and recent postmenopausal [n 37, age 53.3 (SD 3)] women from the Copenhagen Women Study participated in a 3-mo, aerobic high-intensity exercise intervention. Before training, plasma apoM was higher in postmenopausal [1.08 mol/l (SD 0.2)] compared with premenopausal [0.82 mol/l (SD 0.2)] women (P 0.0001). Plasma S1P was similar in the two groups [0.44 mol/l (SD 0.1) and 0.46 mol/l (SD 0.1), respectively]. Thus, the pretraining S1P/apoM ratio was 26% lower in postmenopausal than premenopausal women (P 0.0001). After the training program, plasma apoM increased from 0.82 mol/l (SD 0.2) to 0.90 mol/l (SD 0.3) in premenopausal women and from 1.08 mol/l (SD 0.2) to 1.16 mol/l (SD 0.3) in postmenopausal women (P 0.05). Plasma S1P increased from 0.44 mol/l (SD 0.1) to 0.47 mol/l (SD 0.1) in premenopausal women and from 0.46 mol/l (SD 0.1) to 0.48 mol/l (SD 0.1) in postmenopausal women (P 0.05). The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status.
KW - Faculty of Science
KW - Apolipoproteins
KW - Lipoprotein metabolism
KW - Lipids
KW - Sphingolipids
KW - Atherosclerosis
KW - Menopausal transition
KW - Cardiovascular training
U2 - 10.1152/japplphysiol.00527.2018
DO - 10.1152/japplphysiol.00527.2018
M3 - Journal article
C2 - 30433864
SN - 8750-7587
VL - 126
SP - 214
EP - 220
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 1
ER -