Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat

TY - JOUR

T1 - Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development

T2 - Evidence from experimental studies focused primarily on the rat

AU - Jensen, Vivi F.H.

AU - Mølck, Anne Marie

AU - Lykkesfeldt, Jens

AU - Bøgh, Ingrid B.

PY - 2018/4

Y1 - 2018/4

N2 - Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.

AB - Glucose is the major energy substrate during embryogenesis and the embryo is dependent on glucose from the maternal circulation to ensure normal metabolism and growth. The placenta plays a key role in this nutrient transfer in mammals, both during embryogenesis and after the development of the chorio-allantoic placental circulation. Maternal hypoglycaemia is accompanied by foetal hypoglycaemia and maternal counter-regulatory measures including a priority to keep nutrients in the maternal circulation by restricting their transfer to the foetus. Concomitantly, the foetus initiates its own counter-regulatory attempt to secure nutrients for its development and survival. Despite these measures, there is a general decrease in nutrient transfer to the foetus, which may have severe consequences for foetal development such as malformations and delayed skeletal development.

KW - Fetal development

KW - Gestation

KW - Intra-uterine growth restriction

KW - Malformations

KW - Maternal hypoglycemia

KW - Materno-foetal nutrient transfer

KW - Skeletal development

U2 - 10.1016/j.reprotox.2018.01.007

DO - 10.1016/j.reprotox.2018.01.007

M3 - Review

C2 - 29408374

AN - SCOPUS:85041748155

SN - 0890-6238

VL - 77

SP - 1

EP - 24

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -