Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing: A Cross-Sectional MRI Study

Bjarke B Hansen; Tom Bendix; Jacob Grindsted; Henning Bliddal; Robin Christensen; Philip Hansen; Robert G C Riis; Mikael Boesen

doi:10.1097/BRS.0000000000001120

Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing: A Cross-Sectional MRI Study

Bjarke B Hansen, Tom Bendix, Jacob Grindsted, Henning Bliddal, Robin Christensen, Philip Hansen, Robert G C Riis, Mikael Boesen

19 Citationer (Scopus)

Abstract

Study Design. Cross-sectional study. Objective. To examine the influence of low-back pain (LBP) and lumbar disc degeneration (LDD) on the lumbar lordosis in weight-bearing positional magnetic resonance imaging (pMRI). Summary of Background Data. The lumbar lordosis increases with a change of position from supine to standing and is known as an essential contributor to dynamic changes. However, the lordosis may be affected by disc degeneration and pain. Methods. Patients with LBP >40 on a 0 to 100mm Visual Analog Scale (VAS) both during activity and rest and a sex and age-decade matching control group without LBP were scanned in the supine and standing position in a 0.25-T open MRI unit. LDD was graded using Pfirrmann's grading-scale. Subsequently, the L2-to-S1 lumbar lordosis angle (LA) was measured. Results. Thirty-eight patients with an average VAS of 58 (±13.8) mm during rest and 75 (±5.0) mm during activities, and 38 healthy controls were included. MRI findings were common in both groups, whereas, the summation of the Pfirrmann's grades (LDD-score) was significantly higher in the patients [(MD 1.44; 95% confidence intervals (CI) 0.80 to 2.10; P<0.001]. The patients were less lordotic than the controls in both the supine (MD -6.4°; 95% CI -11.4 to -1.3), and standing position (MD -5.6°; 95% CI -10.7 to -0.7); however, the changes between the positions (DLA) were the same (MD 0.88; 95% CI -1.8 to 3.3). Using generalized linear model the LDDscore was associated with age (P<0.001) for both groups. The LDD-score and DLA were negatively associated in the control group (P<0.001), also after adjustments for gender and age (β-coefficient: -2.66; 95% CI -4.3 to -1.0; P=0.002). Conclusion. Patients may be less lordotic in both the supine and standing position, whereas, change in the lordosis between the positions may be independent of pain. Decreasing lordosis change seems to be associated with age-related increasing disc degeneration in healthy individuals.

Originalsprog	Engelsk
Tidsskrift	Spine
Vol/bind	40
Udgave nummer	21
Sider (fra-til)	1690-6
Antal sider	7
ISSN	0362-2436
DOI	https://doi.org/10.1097/BRS.0000000000001120
Status	Udgivet - 27 okt. 2015

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10.1097/BRS.0000000000001120

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@article{41b6b70f8da34daaaab7edc91db8c33f,

title = "Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing: A Cross-Sectional MRI Study",

abstract = "Study Design. Cross-sectional study. Objective. To examine the influence of low-back pain (LBP) and lumbar disc degeneration (LDD) on the lumbar lordosis in weight-bearing positional magnetic resonance imaging (pMRI). Summary of Background Data. The lumbar lordosis increases with a change of position from supine to standing and is known as an essential contributor to dynamic changes. However, the lordosis may be affected by disc degeneration and pain. Methods. Patients with LBP >40 on a 0 to 100mm Visual Analog Scale (VAS) both during activity and rest and a sex and age-decade matching control group without LBP were scanned in the supine and standing position in a 0.25-T open MRI unit. LDD was graded using Pfirrmann's grading-scale. Subsequently, the L2-to-S1 lumbar lordosis angle (LA) was measured. Results. Thirty-eight patients with an average VAS of 58 (±13.8) mm during rest and 75 (±5.0) mm during activities, and 38 healthy controls were included. MRI findings were common in both groups, whereas, the summation of the Pfirrmann's grades (LDD-score) was significantly higher in the patients [(MD 1.44; 95% confidence intervals (CI) 0.80 to 2.10; P<0.001]. The patients were less lordotic than the controls in both the supine (MD -6.4°; 95% CI -11.4 to -1.3), and standing position (MD -5.6°; 95% CI -10.7 to -0.7); however, the changes between the positions (DLA) were the same (MD 0.88; 95% CI -1.8 to 3.3). Using generalized linear model the LDDscore was associated with age (P<0.001) for both groups. The LDD-score and DLA were negatively associated in the control group (P<0.001), also after adjustments for gender and age (β-coefficient: -2.66; 95% CI -4.3 to -1.0; P=0.002). Conclusion. Patients may be less lordotic in both the supine and standing position, whereas, change in the lordosis between the positions may be independent of pain. Decreasing lordosis change seems to be associated with age-related increasing disc degeneration in healthy individuals.",

author = "Hansen, {Bjarke B} and Tom Bendix and Jacob Grindsted and Henning Bliddal and Robin Christensen and Philip Hansen and Riis, {Robert G C} and Mikael Boesen",

year = "2015",

month = oct,

day = "27",

doi = "10.1097/BRS.0000000000001120",

language = "English",

volume = "40",

pages = "1690--6",

journal = "Spine",

issn = "0362-2436",

publisher = "Lippincott Williams & Wilkins",

number = "21",

}

TY - JOUR

T1 - Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing

T2 - A Cross-Sectional MRI Study

AU - Hansen, Bjarke B

AU - Bendix, Tom

AU - Grindsted, Jacob

AU - Bliddal, Henning

AU - Christensen, Robin

AU - Hansen, Philip

AU - Riis, Robert G C

AU - Boesen, Mikael

PY - 2015/10/27

Y1 - 2015/10/27

N2 - Study Design. Cross-sectional study. Objective. To examine the influence of low-back pain (LBP) and lumbar disc degeneration (LDD) on the lumbar lordosis in weight-bearing positional magnetic resonance imaging (pMRI). Summary of Background Data. The lumbar lordosis increases with a change of position from supine to standing and is known as an essential contributor to dynamic changes. However, the lordosis may be affected by disc degeneration and pain. Methods. Patients with LBP >40 on a 0 to 100mm Visual Analog Scale (VAS) both during activity and rest and a sex and age-decade matching control group without LBP were scanned in the supine and standing position in a 0.25-T open MRI unit. LDD was graded using Pfirrmann's grading-scale. Subsequently, the L2-to-S1 lumbar lordosis angle (LA) was measured. Results. Thirty-eight patients with an average VAS of 58 (±13.8) mm during rest and 75 (±5.0) mm during activities, and 38 healthy controls were included. MRI findings were common in both groups, whereas, the summation of the Pfirrmann's grades (LDD-score) was significantly higher in the patients [(MD 1.44; 95% confidence intervals (CI) 0.80 to 2.10; P<0.001]. The patients were less lordotic than the controls in both the supine (MD -6.4°; 95% CI -11.4 to -1.3), and standing position (MD -5.6°; 95% CI -10.7 to -0.7); however, the changes between the positions (DLA) were the same (MD 0.88; 95% CI -1.8 to 3.3). Using generalized linear model the LDDscore was associated with age (P<0.001) for both groups. The LDD-score and DLA were negatively associated in the control group (P<0.001), also after adjustments for gender and age (β-coefficient: -2.66; 95% CI -4.3 to -1.0; P=0.002). Conclusion. Patients may be less lordotic in both the supine and standing position, whereas, change in the lordosis between the positions may be independent of pain. Decreasing lordosis change seems to be associated with age-related increasing disc degeneration in healthy individuals.

AB - Study Design. Cross-sectional study. Objective. To examine the influence of low-back pain (LBP) and lumbar disc degeneration (LDD) on the lumbar lordosis in weight-bearing positional magnetic resonance imaging (pMRI). Summary of Background Data. The lumbar lordosis increases with a change of position from supine to standing and is known as an essential contributor to dynamic changes. However, the lordosis may be affected by disc degeneration and pain. Methods. Patients with LBP >40 on a 0 to 100mm Visual Analog Scale (VAS) both during activity and rest and a sex and age-decade matching control group without LBP were scanned in the supine and standing position in a 0.25-T open MRI unit. LDD was graded using Pfirrmann's grading-scale. Subsequently, the L2-to-S1 lumbar lordosis angle (LA) was measured. Results. Thirty-eight patients with an average VAS of 58 (±13.8) mm during rest and 75 (±5.0) mm during activities, and 38 healthy controls were included. MRI findings were common in both groups, whereas, the summation of the Pfirrmann's grades (LDD-score) was significantly higher in the patients [(MD 1.44; 95% confidence intervals (CI) 0.80 to 2.10; P<0.001]. The patients were less lordotic than the controls in both the supine (MD -6.4°; 95% CI -11.4 to -1.3), and standing position (MD -5.6°; 95% CI -10.7 to -0.7); however, the changes between the positions (DLA) were the same (MD 0.88; 95% CI -1.8 to 3.3). Using generalized linear model the LDDscore was associated with age (P<0.001) for both groups. The LDD-score and DLA were negatively associated in the control group (P<0.001), also after adjustments for gender and age (β-coefficient: -2.66; 95% CI -4.3 to -1.0; P=0.002). Conclusion. Patients may be less lordotic in both the supine and standing position, whereas, change in the lordosis between the positions may be independent of pain. Decreasing lordosis change seems to be associated with age-related increasing disc degeneration in healthy individuals.

U2 - 10.1097/BRS.0000000000001120

DO - 10.1097/BRS.0000000000001120

M3 - Journal article

C2 - 26502098

SN - 0362-2436

VL - 40

SP - 1690

EP - 1696

JO - Spine

JF - Spine

IS - 21

ER -

Effect of Lumbar Disc Degeneration and Low-Back Pain on the Lumbar Lordosis in Supine and Standing: A Cross-Sectional MRI Study

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